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联合流感嗜血杆菌 b 型-脑膜炎奈瑟球菌 C 群结合疫苗加强剂与麻疹、腮腺炎和风疹疫苗同时接种的反应原性和免疫原性。

Reactogenicity and immunogenicity of combined Haemophilus influenzae type b-meningococcal serogroup C conjugate vaccine booster dose coadministered with measles, mumps, and rubella vaccine.

机构信息

Instituto Hispalense de Pediatría, Sevilla, Spain.

出版信息

Pediatr Infect Dis J. 2010 Mar;29(3):269-71. doi: 10.1097/INF.0b013e3181c15977.

DOI:10.1097/INF.0b013e3181c15977
PMID:19952860
Abstract

A booster dose of Haemophilus influenzae type b-Neisseria meningitidis serogroup C conjugate (Hib-MenC-TT) vaccine simultaneously administered with measles, mumps, and rubella (MMR) vaccine in 13- to 14-month-old Spanish toddlers, primed with 3 doses of a combined Diphteria-Tetanus-Acellular Pertusis DTPa-Hib-containing vaccine and a MenC-CRM197 conjugate vaccine, had a good reactogenicity profile and induced similar Hib and MenC booster responses and MMR seropositivity rates as the vaccines given alone.

摘要

在西班牙 13 至 14 个月大的幼儿中，同时接种一剂含 Hib-MenC 结合型（TT）疫苗的流感嗜血杆菌 b 型-脑膜炎奈瑟菌 C 群（Hib-MenC-TT）疫苗和麻疹、腮腺炎和风疹（MMR）疫苗，这些幼儿之前已接种了 3 剂含白喉、破伤风、无细胞百日咳、Hib 的联合疫苗（DTaP-Hib）和脑膜炎 C 群 CRM197 结合型疫苗（MenC-CRM197 结合型疫苗），其具有良好的反应原性，诱导 Hib 和 MenC 加强免疫应答以及 MMR 血清阳性率与单独接种疫苗相似。

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Reactogenicity and immunogenicity of combined Haemophilus influenzae type b-meningococcal serogroup C conjugate vaccine booster dose coadministered with measles, mumps, and rubella vaccine.联合流感嗜血杆菌 b 型-脑膜炎奈瑟球菌 C 群结合疫苗加强剂与麻疹、腮腺炎和风疹疫苗同时接种的反应原性和免疫原性。
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引用本文的文献

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Antibody Persistence in Young Children 5 Years after Vaccination with a Combined Haemophilus influenzae Type b-Neisseria meningitidis Serogroup C Conjugate Vaccine Coadministered with Diphtheria-Tetanus-Acellular Pertussis-Based and Pneumococcal Conjugate Vaccines.在接种b型流感嗜血杆菌-脑膜炎奈瑟菌C群结合疫苗并同时接种白喉-破伤风-无细胞百日咳疫苗和肺炎球菌结合疫苗5年后幼儿体内抗体的持久性
Clin Vaccine Immunol. 2016 Jul 5;23(7):555-63. doi: 10.1128/CVI.00057-16. Print 2016 Jul.
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Conjugate Meningococcal Vaccines Development: GSK Biologicals Experience.结合型脑膜炎球菌疫苗的研发：葛兰素史克生物制品公司的经验
Adv Prev Med. 2011;2011:846756. doi: 10.4061/2011/846756. Epub 2011 Jul 18.