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PharmGKB very important pharmacogene: SLCO1B1.

作者信息

Oshiro Connie, Mangravite Lara, Klein Teri, Altman Russ

机构信息

Department of Genetics, Stanford University, CA, USA.

出版信息

Pharmacogenet Genomics. 2010 Mar;20(3):211-6. doi: 10.1097/FPC.0b013e328333b99c.

DOI:10.1097/FPC.0b013e328333b99c
PMID:19952871
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3086841/
Abstract
摘要

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Genome-wide association meta-analysis for total serum bilirubin levels.全基因组关联荟萃分析血清总胆红素水平
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2
Comprehensive pharmacogenetic analysis of irinotecan neutropenia and pharmacokinetics.伊立替康所致中性粒细胞减少症及药代动力学的综合药物遗传学分析
J Clin Oncol. 2009 Jun 1;27(16):2604-14. doi: 10.1200/JCO.2008.20.6300. Epub 2009 Apr 6.
3
Effects of gemfibrozil and atorvastatin on the pharmacokinetics of repaglinide in relation to SLCO1B1 polymorphism.吉非贝齐和阿托伐他汀对瑞格列奈药代动力学的影响与溶质载体有机阴离子转运体1B1（SLCO1B1）基因多态性的关系
Clin Pharmacol Ther. 2008 Oct;84(4):488-96. doi: 10.1038/clpt.2008.74.
4
Genetic variations of the SLCO1B1 gene in the Chinese, Malay and Indian populations of Singapore.新加坡华裔、马来裔和印度裔人群中SLCO1B1基因的遗传变异。
Drug Metab Pharmacokinet. 2008;23(6):476-82. doi: 10.2133/dmpk.23.476.
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Life-threatening toxicities in a patient with UGT1A1*6/*28 and SLCO1B1*15/*15 genotypes after irinotecan-based chemotherapy.在接受基于伊立替康的化疗后，一名UGT1A1*6/*28和SLCO1B1*15/*15基因型患者出现危及生命的毒性反应。
Cancer Chemother Pharmacol. 2009 May;63(6):1165-9. doi: 10.1007/s00280-008-0864-x. Epub 2008 Nov 8.
6
The effect of SLCO1B1 polymorphism on repaglinide pharmacokinetics persists over a wide dose range.SLCO1B1基因多态性对瑞格列奈药代动力学的影响在很宽的剂量范围内持续存在。
Br J Clin Pharmacol. 2008 Dec;66(6):818-25. doi: 10.1111/j.1365-2125.2008.03287.x. Epub 2008 Sep 23.
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Association between a frequent allele of the gene encoding OATP1B1 and enhanced LDL-lowering response to fluvastatin therapy.编码OATP1B1的基因的常见等位基因与氟伐他汀治疗后LDL降低反应增强之间的关联。
Pharmacogenomics. 2008 Sep;9(9):1217-27. doi: 10.2217/14622416.9.9.1217.
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Amino acid residues in transmembrane domain 10 of organic anion transporting polypeptide 1B3 are critical for cholecystokinin octapeptide transport.有机阴离子转运多肽1B3跨膜结构域10中的氨基酸残基对胆囊收缩素八肽的转运至关重要。
Biochemistry. 2008 Sep 2;47(35):9090-7. doi: 10.1021/bi8008455. Epub 2008 Aug 9.
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SLCO1B1 variants and statin-induced myopathy--a genomewide study.溶质载体有机阴离子转运体家族1成员B1（SLCO1B1）变异与他汀类药物诱发的肌病——一项全基因组研究
N Engl J Med. 2008 Aug 21;359(8):789-99. doi: 10.1056/NEJMoa0801936. Epub 2008 Jul 23.
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Pharmacokinetic interaction between pravastatin and olmesartan in relation to SLCO1B1 polymorphism.普伐他汀与奥美沙坦之间的药代动力学相互作用与溶质载体有机阴离子转运体1B1（SLCO1B1）基因多态性的关系。
J Hum Genet. 2008;53(10):899-904. doi: 10.1007/s10038-008-0324-9. Epub 2008 Jul 19.