Traverso Luis Miguel, Quintero Esperanza, Vargas Juan Pedro, De la Casa Luis Gonzalo, Lopez Juan Carlos
Department of Experimental Psychology, Lab Neurociencia de la Conducta, University of Seville, Spain.
Neuroreport. 2010 Jan 27;21(2):99-103. doi: 10.1097/WNR.0b013e328334888a.
N-methyl-D-aspartate receptor has been related to learning and memory processes. Its characteristics make it a key candidate in the modulation of associative processes at physiological level. Traditionally, the main efforts have been directed to show its role in excitatory conditioning. Nevertheless, the studies that have analyzed its implication in inhibitory learning are scarce. We present an experiment where a preexposure effect on the conditioning (latent inhibition) is disrupted by 2-amino-5-phosphonopentanoic acid administered in basolateral amygdala. This data shows interference on taste memory trace, and attenuation of the inhibition effect.
N-甲基-D-天冬氨酸受体与学习和记忆过程相关。其特性使其成为生理水平上联想过程调节的关键候选者。传统上，主要努力方向是证明其在兴奋性条件作用中的作用。然而，分析其在抑制性学习中所起作用的研究却很少。我们进行了一项实验，在基底外侧杏仁核中注射2-氨基-5-磷酸戊酸会破坏对条件作用的预暴露效应（潜伏抑制）。该数据显示对味觉记忆痕迹有干扰，且抑制作用减弱。
