Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Pancreas. 2010 Jan;39(1):31-5. doi: 10.1097/MPA.0b013e3181c31049.
The purpose of this study was to examine CD44v6 expression in intraductal papillary mucinous neoplasms (IPMNs) and clarify the role of CD44v6 in progression, invasion, metastasis, and morphogenesis of IPMNs.
One hundred fifty-one samples of IPMNs and 30 normal controls were subjected to immunohistochemical analysis for CD44v6. The IPMNs were divided into 4 groups according to the grade of atypia (adenoma, borderline IPMN, noninvasive carcinoma, and invasive carcinoma) and 5 subtypes according to histological phenotype (gastric, intestinal, pancreatobiliary, oncocytic, and unclassified). Correlations were investigated between CD44v6 expression and clinicopathological characteristics including grade of atypia, subtype, lymph node metastasis, and invasion pattern.
Whereas normal ductal epithelium did not express CD44v6, CD44v6 expression was observed from the early stage of IPMNs and up-regulated in the progression of IPMNs to invasive carcinoma. CD44v6 expression in intestinal-type IPMNs was significantly lower compared with that in other subtypes. Whereas no correlation was observed between lymph node metastasis and CD44v6 expression in invasive IPM carcinomas, the invasion pattern was significantly correlated to CD44v6 expression.
The present data indicate that CD44v6 expression determines the morphology and aggressiveness of IPMNs and is involved in development and invasion of IPMNs.
本研究旨在检测 CD44v6 在导管内乳头状黏液性肿瘤（IPMNs）中的表达，并阐明 CD44v6 在 IPMNs 的进展、浸润、转移和形态发生中的作用。
对 151 例 IPMNs 样本和 30 例正常对照进行 CD44v6 免疫组织化学分析。根据异型增生程度（腺瘤、交界性 IPMN、非浸润性癌和浸润性癌）将 IPMNs 分为 4 组，并根据组织学表型（胃型、肠型、胰胆管型、嗜酸细胞型和未分类型）分为 5 个亚型。研究了 CD44v6 表达与包括异型增生程度、亚型、淋巴结转移和浸润模式在内的临床病理特征之间的相关性。
正常导管上皮不表达 CD44v6，而在 IPMNs 的早期就观察到 CD44v6 的表达，并在 IPMNs 向浸润性癌的进展中上调。肠型 IPMNs 中 CD44v6 的表达明显低于其他亚型。在浸润性 IPMN 癌中，淋巴结转移与 CD44v6 表达之间无相关性，但浸润模式与 CD44v6 表达显著相关。
本研究数据表明，CD44v6 表达决定了 IPMNs 的形态和侵袭性，并参与了 IPMNs 的发生和浸润。
