血清糖化白蛋白参考值的多中心临床研究

[A multi-center clinical study of the reference value of serum glycated albumin].

作者信息

Zhou Jian, Li Hong, Yang Wen-Ying, Ran Xing-Wu, Li Qiang, Peng Yong-De, Li Yan-Bing, Gao Xin, Luan Xiao-Jun, Wang Wei-Qing, Jia Wei-Ping

机构信息

Department of Endocrinology and Metabolism, Shanghai Jiao Tong University, Affiliated Sixth People's Hospital, Shanghai, China.

出版信息

Zhonghua Nei Ke Za Zhi. 2009 Jun;48(6):469-72.

PMID:19954041

Abstract

OBJECTIVE

To set up the reference value of serum glycated albumin (GA) in Chinese for using in clinical practice through a multi-center clinical trial.

METHODS

Three hundred and eighty individuals with normal weight and normal glucose regulation, including 183 males and 197 females ranging from 20 to 69 years, were recruited from 10 hospitals in China Serum GA levels were measured with liquid enzymatic method.

RESULTS

(1) The GA level of the 380 subjects was (14.5 +/- 1.9)%. When dividing these subjects by age into 3 subgroups, there was no difference in the GA levels among the 3 subgroups (P > 0.05). Compared with the women, the men had higher GA level in the first subgroup aging from 20 to 39 (P = 0.028). However, no significant difference was detected after adjusting with BMI as confounder. (2) When dividing those subjects by BMI into 3 subgroups, with BMI ranging from 18.5-20.9 kg/m2 21.0-22.9 kg/m2 and 23.0-24.9 kg/m2 respectively, we came to the following results: for men, there was no difference in the GA levels among the 3 subgroups (P > 0.05), but for women, the GA level of the first subgroup was higher than that of the second subgroup (P = 0.024). (3) The level of GA in the 2.5th to 97.5th percentile was 10.8%-17.1%. (4) Sixty normal subjects were chosen to repeat evaluation of GA levels after 2-3 weeks and the GA levels were of no difference (P > 0.05).

CONCLUSION

The normal range of serum GA for the Chinese population could be suggested at 11%-17%.

摘要

目的

通过多中心临床试验建立糖化血清白蛋白（GA）在中国人群中的临床应用参考值。

方法

从中国10家医院招募380名体重正常且糖代谢正常的个体，年龄在20至69岁之间，其中男性183名，女性197名。采用液相酶法测定血清GA水平。

结果

（1）380名受试者的GA水平为（14.5±1.9）%。将这些受试者按年龄分为3个亚组，3个亚组间GA水平无差异（P>0.05）。在20至39岁的第一亚组中，男性的GA水平高于女性（P=0.028）。然而，以BMI作为混杂因素进行校正后，未检测到显著差异。（2）将这些受试者按BMI分为3个亚组，BMI分别为18.5 - 20.9kg/m²、21.0 - 22.9kg/m²和23.0 - 24.9kg/m²，结果如下：男性3个亚组间GA水平无差异（P>0.05），但女性中，第一亚组的GA水平高于第二亚组（P=0.024）。（3）第2.5至97.5百分位数的GA水平为10.8% - 17.1%。（4）选择60名正常受试者在2 - 3周后重复评估GA水平，GA水平无差异（P>0.05）。