Zhou Qiang, Shi De-Bao, Lv Li-Ying
Department of Clinical Laboratory, The Second Affiliated Hospital of Anhui Medical University, Hefei, China.
Department of Clinical Laboratory, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
J Clin Lab Anal. 2017 Sep;31(5). doi: 10.1002/jcla.22097. Epub 2016 Nov 17.
We established the reference intervals for glycated albumin (GA), fructosamine (FA), and 1,5-anhydroglucitol (1,5-AG) in a Chinese healthy population.
This study enrolled a total of 458 eligible reference individuals, consisted of 226 men and 232 women, aged from 20~79 years (median age 43 years), who attending routine healthy checks. We stratified the subjects according to gender (males and females) and age (20-39, 40-59, and 60-79 years), and combined statistical methods with Lahti algorithm, as well as appropriate clinical consideration, to judge whether partitioning for data was needed.
Glycated albumin levels between males and females were statistically different (P<.001), but the absolute difference between the upper reference limits was only 0.31%, which was too small to be clinically relevant. GA levels across the three age groups were statistically different (P<.001), and Lahti algorithm suggested partitioning for 20-59 and 60-79 years, which reference intervals were 10.38%-13.89% and 10.23%-14.79%, respectively. 1,5-AG levels in males were significant higher than females (P<.001), and absolute difference was 51 μmol/L (8.5 μg/mL) in mean level. Thus, partitioning for gender was needed. Reference intervals for 1,5-AG were 107-367 μmol/L for males and 79-306 μmol/L for females. The absolute difference of the lower reference limits for FA was only 7 μmol/L between males and females. FA levels across the three age groups were not statistically different (P>.05). The reference interval for FA was 220-298 μmol/L.
New reference intervals for nontraditional glycemic markers were established based on a Chinese population.
我们建立了中国健康人群糖化白蛋白（GA）、果糖胺（FA）和1,5-脱水葡萄糖醇（1,5-AG）的参考区间。
本研究共纳入458名符合条件的参考个体，包括226名男性和232名女性，年龄在20至79岁之间（中位年龄43岁），均参加了常规健康检查。我们根据性别（男性和女性）和年龄（20 - 39岁、40 - 59岁和60 - 79岁）对受试者进行分层，并结合统计方法与拉赫蒂算法以及适当的临床考量，来判断是否需要对数据进行分组。
男性和女性之间的糖化白蛋白水平存在统计学差异（P <.001），但参考上限之间的绝对差异仅为0.31%，过小以至于在临床上无显著意义。三个年龄组的GA水平存在统计学差异（P <.001），拉赫蒂算法建议对20 - 59岁和60 - 79岁进行分组，其参考区间分别为10.38% - 13.89%和10.23% - 14.79%。男性的1,5-AG水平显著高于女性（P <.001），平均水平的绝对差异为51μmol/L（8.5μg/mL）。因此，需要按性别进行分组。男性1,5-AG的参考区间为107 - 367μmol/L，女性为79 - 306μmol/L。男性和女性之间FA参考下限的绝对差异仅为7μmol/L。三个年龄组的FA水平无统计学差异（P >.05）。FA的参考区间为220 - 298μmol/L。
基于中国人群建立了非传统血糖标志物的新参考区间。
