Department of Gastroenterology, The People's Hospital of Deyang City, Deyang, Sichuan, China.
Cancer Biother Radiopharm. 2009 Dec;24(6):733-5. doi: 10.1089/cbr.2009.0683.
Published data on hedgehog (Hh) pathway activation in colorectal cancer (CRC) are conflicting, and the effect of the Hh pathway inhibitor on the viability of colon cancer cells is controversial. This article focuses attention on the often-neglected, yet likely, critical role of Indian Hh in the course of colonic tumor progression and hypothesizes that upregulation of Indian Hh expression may offer a novel therapeutic approach against CRC through inducing differentiation of tumor cells and through abrogating the Sonic Hh signaling that drives CRC growth.
有关 Hedgehog（Hh）通路在结直肠癌（CRC）中的激活的发表数据存在争议，Hh 通路抑制剂对结肠癌细胞活力的影响也存在争议。本文重点关注经常被忽视但可能至关重要的印度 Hh 在结肠肿瘤进展过程中的作用，并假设上调印度 Hh 表达可能通过诱导肿瘤细胞分化和阻断驱动 CRC 生长的 Sonic Hh 信号来提供一种针对 CRC 的新的治疗方法。
