Sivamurthy Krupa M, Dampier Carlton, MacDermott MaryLou, Maureen Meier, Cahill Michele, Hsu Lewis L
Hematology/Oncology, St. Christopher's Hospital for Children, Philadelphia, Pennsylvania 19141, USA.
Pediatr Hematol Oncol. 2009 Nov;26(8):589-96. doi: 10.3109/08880010903271689.
SCD is characterized by hemolysis and oxidative stress, resulting in endothelial dysfunction (EDF). Peripheral arterial tonometry (PAT), a noninvasive technology for measuring EDF, utilizes reactive hyperemia following mini-ischemic stress (reactive hyperemia index or RHI).
The authors studied PAT in 36 SCD children to determine the influence of hemoglobin genotype and treatment on EDF.
Blunted RHI was seen in the majority of children with SCD, especially with increased symptomatology (1.53 and 1.71; p value .032). RHI was not normal in children on chronic transfusion or hydroxyurea. RHI correlated with reticulocyte fraction (Spearman r = -.47, p = .037). PAT merits further exploration as a measure of EDF in SCD.
镰状细胞病（SCD）的特征为溶血和氧化应激，可导致内皮功能障碍（EDF）。外周动脉张力测量法（PAT）是一种用于测量EDF的非侵入性技术，它利用小缺血应激后的反应性充血（反应性充血指数或RHI）。
作者对36名SCD儿童进行了PAT研究，以确定血红蛋白基因型和治疗对EDF的影响。
大多数SCD儿童的RHI降低，尤其是症状加重的儿童（分别为1.53和1.71；p值为0.032）。接受慢性输血或羟基脲治疗的儿童RHI未恢复正常。RHI与网织红细胞分数相关（Spearman相关系数r = -0.47，p = 0.037）。作为一种测量SCD中EDF的方法，PAT值得进一步探索。
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