[淋巴瘤细胞白血病的病理类型及临床特征分析]

[Analysis of pathological type and clinical features of lymphoma cell leukemia].

作者信息

Gui Wei, Zhao Zhi-Qiang, Zhang Zong, Guo Yan-Rong, Zhang Qiao-Hua, Su Wen

机构信息

Department of Hematology, Shanxi Tumor Hospital, Taiyuan 030013, China.

出版信息

Zhonghua Xue Ye Xue Za Zhi. 2009 Oct;30(10):662-6.

PMID:19954660

Abstract

OBJECTIVE

To analyze the pathological type and clinical features of patients with lymphoma cell leukemia (LML).

METHODS

According to the 2008 WHO classification of tumors of hematopoietic and lymphoid tissue, the pathological type and clinical features of 127 LML cases were analyzed retrospectively.

RESULTS

There were 15 kinds of NHL developed LML. The incidence in frequent order of them was B-lymphoblastic lymphoma, CLL/small lymphocytic lymphoma (SLL) and T-lymphoblastic lymphoma. The LML of T and B cell subtypes were 45 and 74, respectively. There was a significant difference in overall survival between T-LML and B-LML (P < 0.01). Eighty one patients presented LML at the same time of the NHL diagnosis and 46 during the course (1 - 88 months) of disease. Primary nodal and extranodal NHLs developed LML were 96 and 31 cases, respectively. The clinical manifestations of LBL and SLL patients differed from that of ALL and CLL patients.

CONCLUSION

LML is not a rare manifestation of NHL. Pathological types of NHL developed LML are 15 kinds in our patients. The clinical features of LML patients are somewhat special, especially for primary extranodal LML patients.

摘要

目的

分析淋巴瘤细胞白血病（LML）患者的病理类型及临床特征。

方法

依据2008年世界卫生组织造血与淋巴组织肿瘤分类，对127例LML病例的病理类型及临床特征进行回顾性分析。

结果

有15种非霍奇金淋巴瘤（NHL）发展为LML。其发病率从高到低依次为B淋巴细胞母细胞淋巴瘤、慢性淋巴细胞白血病/小淋巴细胞淋巴瘤（SLL）和T淋巴细胞母细胞淋巴瘤。T细胞亚型和B细胞亚型的LML分别有45例和74例。T-LML和B-LML的总生存期存在显著差异（P < 0.01）。81例患者在NHL诊断时同时出现LML，46例在疾病过程中（1 - 88个月）出现。原发于淋巴结和结外的NHL发展为LML的分别有96例和31例。淋巴母细胞淋巴瘤（LBL）和SLL患者的临床表现与急性淋巴细胞白血病（ALL）和慢性淋巴细胞白血病（CLL）患者不同。