González-Barrientos R, Morales J-A, Hernández-Mora G, Barquero-Calvo E, Guzmán-Verri C, Chaves-Olarte E, Moreno E
Cátedra de Patología, Escuela de Medicina Veterinaria, Universidad Nacional, Heredia, Costa Rica.
J Comp Pathol. 2010 May;142(4):347-52. doi: 10.1016/j.jcpa.2009.10.017. Epub 2009 Dec 2.
Seventeen striped dolphins (Stenella coeruleoalba) displaying swimming disorders compatible with neurological syndromes were investigated for Brucella infection. Sixteen dolphins had meningoencephalomyelitis. Serum antibody against Brucella antigen was detected in all 14 animals tested and Brucella ceti was isolated from eight out of nine animals. Brucella antigen was detected in the brain by immunofluorescence, but not by immunohistochemical labelling. By contrast, Brucella antigen was demonstrated by immunohistochemistry in the trophoblast of animals with severe placentitis and in the mitral valve of animals with myocarditis. The microscopical lesions observed in the tissues of the infected dolphins were similar to those of chronic brucellosis in man. The severity of brucellosis in S. coeruleoalba indicates that this dolphin species is highly susceptible to infection by B. ceti.
对17只表现出与神经综合征相符的游泳障碍的条纹原海豚（Stenella coeruleoalba）进行了布鲁氏菌感染调查。16只海豚患有脑膜脑脊髓炎。在所有14只接受检测的动物中均检测到针对布鲁氏菌抗原的血清抗体，并且从9只动物中的8只分离出了鲸布鲁氏菌。通过免疫荧光在脑中检测到了布鲁氏菌抗原，但免疫组织化学标记未检测到。相比之下，通过免疫组织化学在患有严重胎盘炎动物的滋养层以及患有心肌炎动物的二尖瓣中证实了布鲁氏菌抗原。在受感染海豚组织中观察到的微观病变与人类慢性布鲁氏菌病的病变相似。条纹原海豚中布鲁氏菌病的严重程度表明该海豚物种对鲸布鲁氏菌感染高度易感。
