Institute of Radiology, Azienda Ospedaliero-Universitaria Santa Maria della Misericordia, 33100 Udine, Italy.
Eur J Radiol. 2011 Jul;79(1):147-54. doi: 10.1016/j.ejrad.2009.10.029. Epub 2009 Dec 1.
Stereotactic body radiation therapy (SBRT) is a new radiotherapy treatment method that has been applied to the treatment of Stage I lung cancers in medically inoperable patients, with excellent clinical results. SBRT allows the delivery of a very high radiation dose to the target volume, while minimizing the dose to the adjacent normal tissues. As a consequence, CT findings after SBRT have different appearance, geographic extent and progression timeline compared to those following conventional radiation therapy for lung cancer. In particular, SBRT-induced changes are limited to the "shell" of normal tissue outside the tumor and have a complex shape. When SBRT-induced CT changes have a consolidation/mass-like appearance, the differentiation from tumor recurrence can be very difficult. An understanding of SBRT technique as it relates to the development of SBRT-induced lung injury and familiarity with the full spectrum of CT manifestations are important to facilitate diagnosis and management of lung cancer patients treated with this newly emerging radiotherapy method.
立体定向体部放射治疗（SBRT）是一种新的放射治疗方法，已应用于不能手术的Ⅰ期肺癌患者的治疗，取得了良好的临床效果。SBRT 可使靶区接受非常高的剂量，同时使相邻正常组织的剂量最小化。因此，SBRT 后 CT 表现与肺癌常规放疗后的表现不同，其在地理范围和进展时间线上均有不同。特别是，SBRT 诱导的改变仅限于肿瘤外正常组织的“壳”，且形状复杂。当 SBRT 诱导的 CT 改变呈实变/肿块样时，与肿瘤复发的鉴别非常困难。了解 SBRT 技术与 SBRT 诱导的肺损伤的发展关系，熟悉 CT 表现的全貌，对于采用这种新出现的放射治疗方法治疗肺癌患者的诊断和处理非常重要。
