SW Thames Institute for Renal Research, St. Helier Hospital, London, UK.
Nephron Exp Nephrol. 2010;114(3):e83-92. doi: 10.1159/000262316. Epub 2009 Dec 2.
Connective tissue growth factor (CTGF, CCN2) is a key mediator of tissue fibrosis. CCN2 plays an important role in the development of glomerular and tubulointerstitial fibrosis in progressive kidney diseases. In this review, we discuss the biology of CCN2 with a focus on the regulation of CCN2 gene, cellular mechanisms of profibrotic CCN2 effects and the current in vivo and in vitro evidence for the role of CCN2 in the development of renal fibrosis. We also discuss the therapeutic potential of targeting CCN2 for the treatment of renal fibrosis.
结缔组织生长因子（CTGF，CCN2）是组织纤维化的关键介质。CCN2 在进行性肾脏疾病中肾小球和肾小管间质纤维化的发展中起着重要作用。在这篇综述中，我们讨论了 CCN2 的生物学特性，重点介绍了 CCN2 基因的调节、CCN2 致纤维化作用的细胞机制以及目前体内外证据表明 CCN2 在肾脏纤维化发展中的作用。我们还讨论了针对 CCN2 治疗肾脏纤维化的治疗潜力。
