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改变生物库研究中的默认设置也可以拯救生命。

Changing defaults in biobank research could save lives too.

机构信息

Centre for Research Ethics and Bioethics, Uppsala University, Uppsala, Sweden.

出版信息

Eur J Epidemiol. 2010 Feb;25(2):65-8. doi: 10.1007/s10654-009-9413-0. Epub 2009 Dec 3.

Abstract

In an effort to increase the amount of organs available for transplantation, many countries have implemented presumed consent for organ donation. Presuming a wish to contribute to medical advances through biobank research on previously taken tissue samples could similarly improve health and wellbeing. In this article we analyze common arguments for and against presumed consent for organ donation and assess their relevance in the context of biobank research. In spite of obvious differences between biobank research and organ transplantation the cases for implementing presumption of a positive attitude appear quite analogous. It has repeatedly been shown that a majority of the general population supports these projects and selecting informed consent as the default position decreases the amount of organs and samples available and thus reduces the prospect of promoting health. We conclude that instead of presuming that individuals do not wish to contribute to the advancement of healthcare through biobank research on previously taken samples, ethics committees should presume that they do.

摘要

为了增加可供移植的器官数量,许多国家都实施了推定同意器官捐献制度。假定人们希望通过对先前采集的组织样本进行生物库研究来推动医学进步,这同样可以改善健康和福利。在本文中,我们分析了支持和反对器官捐献推定同意的常见论点,并评估了它们在生物库研究背景下的相关性。尽管生物库研究和器官移植之间存在明显差异,但实施积极态度推定的情况似乎非常类似。大量研究表明,大多数民众支持这些项目,而将知情同意作为默认立场会减少可获得的器官和样本数量,从而降低促进健康的前景。我们的结论是,伦理委员会应该假定人们希望通过对先前采集的样本进行生物库研究来推动医疗保健的发展,而不是假定他们不愿意。

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