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Tumorigenicity of human induced pluripotent stem cells depends on the balance of gene expression between p21 and p53.

作者信息

Moriguchi Hisashi, Chung Raymond T, Sato Chifumi

出版信息

Hepatology. 2010 Mar;51(3):1088-9. doi: 10.1002/hep.23396.

DOI:10.1002/hep.23396
PMID:19957368
Abstract
摘要

相似文献

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Tumorigenicity of human induced pluripotent stem cells depends on the balance of gene expression between p21 and p53.
Hepatology. 2010 Mar;51(3):1088-9. doi: 10.1002/hep.23396.
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Murine fibroblasts lacking p21 undergo senescence and are resistant to transformation by oncogenic Ras.缺乏p21的小鼠成纤维细胞会发生衰老,并且对致癌性Ras诱导的转化具有抗性。
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Princess Takamatsu Symp. 1989;20:221-30.
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Paradoxical tumor inhibitory effect of p53 loss in transgenic mice expressing epidermal-targeted v-rasHa, v-fos, or human transforming growth factor alpha.在表达表皮靶向性v-rasHa、v-fos或人转化生长因子α的转基因小鼠中,p53缺失的矛盾性肿瘤抑制作用。
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[Research on expression and control of p16 and p21 by wild-type p53 gene in two lung adenocarcinoma cell lines].[野生型p53基因对两种肺腺癌细胞系中p16和p21表达及调控的研究]
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Brain cancer stem-like cell genesis from p53-deficient mouse astrocytes by oncogenic Ras.致癌性Ras诱导p53基因缺失的小鼠星形胶质细胞产生脑癌干细胞样细胞。
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p53 and p21/Waf1 protein expression and K-ras codon 12 mutation in carcinoma of the papilla of Vater.p53和p21/Waf1蛋白表达以及胰腺导管腺癌中K-ras密码子12突变
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Immunophenotype, ras oncogenes and p53 onco-suppressor gene in benzo(a)pyrene induced malignant soft tissue tumours in Wistar rats.苯并(a)芘诱导的Wistar大鼠恶性软组织肿瘤中的免疫表型、ras癌基因和p53抑癌基因
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Immunohistochemical expression of fatty acid synthase, apoptotic-regulating genes, proliferating factors, and ras protein product in colorectal adenomas, carcinomas, and adjacent nonneoplastic mucosa.脂肪酸合酶、凋亡调控基因、增殖因子及ras蛋白产物在大肠腺瘤、癌及相邻非肿瘤性黏膜中的免疫组化表达
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TATA box-binding protein-associated factor 12 is important for RAS-induced transformation properties of colorectal cancer cells.TATA盒结合蛋白相关因子12对RAS诱导的结肠癌细胞转化特性很重要。
Mol Cancer Res. 2008 Jun;6(6):1071-83. doi: 10.1158/1541-7786.MCR-07-0375.

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