Ma Cui, Zhang Wei-yuan, Wang Jian-dong
Beijing Gynecology and Obstetrics Hospital Affiliated to Capital Medical University, Beijing 100026, China.
Zhonghua Yi Xue Za Zhi. 2009 Jun 16;89(23):1650-3.
To investigate the different immune functions in normal cervix, CIN and cervical cancer tissue and the relationship between HPV infection and local cervical immune functions.
The morphology, quantity, distribution and optical density of CD4+ Th cells, S-100 dendritic cells and CD57+ NK cells in normal cervical tissue, CIN cervical tissue and cervical cancer tissue were determined by immunohistochemistry and imaging analysis.
In the precancerous lesions, the numbers of the CD4+ Th cells, S-100+ DC and CD57+ NK cells increased with the disease progression in CIN (P < 0.05). But, after carcinogenesis, the immune cells decreased in local cervix tissue (P < 0.05).
The local tissue of human cervical precancerous lesions had more heightened immune functions as compared with the cancer tissue.
