Dimitrakov Jordan, Dimitrakova Elena
Urological Diseases Research Center, Harvard Medical School, Children's Hospital, Boston, USA.
Folia Med (Plovdiv). 2009 Jul-Sep;51(3):42-4.
Urologic chronic pelvic pain syndrome (UCPPS) is a symptom-based umbrella term for interstitial cystitis/painful bladder syndrome (IC/PBS) and chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) in men. Unfortunately, no gold standard for diagnosis or treatment of UCPPS exists. We review several emerging theories on the etiology and pathogenesis of UCPPS with a special emphasis on genomic and proteomic technologies. We also propose a systems-biology approach to elucidating the pathogenetic mechanisms implicated in UCPPS and the discovery and validation of new biomarkers for UCPPS. Using data gleaned from high-throughput genomic and proteomic screens can help develop effective treatments for this enigmatic chronic pelvic pain syndrome.
泌尿外科慢性盆腔疼痛综合征（UCPPS）是一个基于症状的统称，涵盖间质性膀胱炎/膀胱疼痛综合征（IC/PBS）以及男性的慢性前列腺炎/慢性盆腔疼痛综合征（CP/CPPS）。遗憾的是，目前尚无UCPPS诊断或治疗的金标准。我们综述了关于UCPPS病因和发病机制的几种新兴理论，特别强调基因组学和蛋白质组学技术。我们还提出了一种系统生物学方法，以阐明UCPPS涉及的发病机制，并发现和验证UCPPS的新生物标志物。利用从高通量基因组和蛋白质组筛查中收集的数据，有助于开发针对这种神秘慢性盆腔疼痛综合征的有效治疗方法。
