Liu Li-Fang, Zhang Ming-Zhi
STU/CUHK Joint Shantou International Eye Center, Shantou 515041, China.
Zhonghua Yan Ke Za Zhi. 2009 Jul;45(7):663-8.
Glaucoma is characterized by progressive loss of retinal ganglion cell (RGCs), optic nerve atrophy, cupping of the optic disc, and specific visual field deficits. Elevated intraocular pressure (IOP) is considered to be a major risk factor associated with the development of this neuropathy, therefore, elevated IOP has been induced in animals to simulate key aspects of human glaucoma, in order to unlock the mechanism of this disease and seek out new therapeutic strategies. In the following review: (1) models used for the study of hypertensive glaucomatous neuropathy in rodents, (2) assessment of these animal models and (3) their usage will be described.
青光眼的特征是视网膜神经节细胞（RGCs）进行性丧失、视神经萎缩、视盘凹陷和特定的视野缺损。眼内压（IOP）升高被认为是与这种神经病变发展相关的主要危险因素，因此，已在动物中诱导眼压升高以模拟人类青光眼的关键方面，以便揭示该疾病的机制并寻找新的治疗策略。在以下综述中，将描述：（1）用于研究啮齿动物高血压性青光眼神经病变的模型，（2）对这些动物模型的评估，以及（3）它们的用途。
