Sultanova U A, Karimov Kh Ia, Khuzhakhmedov Zh D
Lik Sprava. 2009 Apr-Jun(3-4):27-31.
Aplastic anaemia (AA) in connection with liver damage is characterized by severe course of the disease, significant shift of the myelogram, considerable changes of blood picture, high lethality, taking in this pathological process various organs and digestion systems. Results of ultrasonic and biochemical researches show presence of deep changes in the liver, gall bladder and pancreas. The disbalance of lipid peroxidation and antioxidative protection system have been observed in these patients. It is revealed by decrease in the activity of enzymes of superoxide dismutase, glutathione peroxidase and catalase, in increase in capacity of intermediate and end products of POL. It is especially expressed in combination of AA with liver damage. That's why it is necessary to provide a constant control of these organs.
与肝损伤相关的再生障碍性贫血（AA）具有病情严重、骨髓象显著改变、血象明显变化、致死率高的特点，该病理过程累及多个器官和消化系统。超声和生化研究结果显示肝脏、胆囊和胰腺存在深度病变。在这些患者中观察到脂质过氧化和抗氧化保护系统失衡。表现为超氧化物歧化酶、谷胱甘肽过氧化物酶和过氧化氢酶的活性降低，POL中间产物和终产物含量增加。这在AA合并肝损伤时尤为明显。因此，有必要对这些器官进行持续监测。
