Department of Biochemistry, University of Oulu, Oulu, Finland.
Antioxid Redox Signal. 2010 Aug 15;13(4):525-37. doi: 10.1089/ars.2009.2996.
Peroxisomes are multifunctional organelles with an important role in the generation and decomposition of reactive oxygen species (ROS). In this review, the ROS-producing enzymes, as well as the antioxidative defense system in mammalian peroxisomes, are described. In addition, various conditions leading to disturbances in peroxisomal ROS metabolism, such as abnormal peroxisomal biogenesis, hypocatalasemia, and proliferation of peroxisomes are discussed. We also review the role of mammalian peroxisomes in some physiological and pathological processes involving ROS that lead to mitochondrial abnormalities, defects in cell proliferation, and alterations in the central nervous system, alcoholic cardiomyopathy, and aging. Antioxid.
过氧化物酶体是多功能细胞器，在活性氧（ROS）的产生和分解中起着重要作用。在这篇综述中，描述了产生 ROS 的酶以及哺乳动物过氧化物酶体中的抗氧化防御系统。此外，还讨论了导致过氧化物酶体 ROS 代谢紊乱的各种情况，如异常过氧化物酶体生物发生、低过氧化氢酶血症和过氧化物酶体增殖。我们还回顾了哺乳动物过氧化物酶体在一些涉及 ROS 的生理和病理过程中的作用，这些过程导致线粒体异常、细胞增殖缺陷以及中枢神经系统、酒精性心肌病和衰老的改变。抗氧化。
