Perez Ronen, Adelman Cahtia, Sichel Jean Yves, Freeman Sharon, Sohmer Haim
Department of Otolaryngology and Head and Neck Surgery, Shaare Zedek Medical Center, Hebrew University-Hadassah Medical School, Jerusalem, Israel.
Acta Otolaryngol. 2010 Jun;130(6):659-64. doi: 10.3109/00016480903373740.
A hole in the vestibule of the inner ear leads to augmentation of the hearing loss following noise exposure. Further research is needed to ascertain the mechanism.
The possible effects of a hole in the wall of the inner ear at the vestibule on noise-induced hearing loss were assessed.
The study was conducted on a total of 14 sand rats. Of these 14 animals, 10 underwent baseline auditory nerve and brainstem evoked response (ABR) threshold measurements in each ear separately (insert earphone), opening of middle ear bulla in both ears and drilling of a hole in the vestibule of one inner ear. The other ear was sham-operated. Following immediate re-assessment of ABR threshold, the 10 animals were exposed to 113 dB SPL broadband noise during 4 nights, and 3 days later ABR measurements were repeated. Four additional animals with a hole in one vestibule, not exposed to noise, served as controls.
Following noise exposure, ABR thresholds were elevated by 28.5 +/- 9.1 dB in the ears with the hole, and by 15.5 +/- 7.2 dB in the opposite ear without the hole (significant difference, p < 0.003). In the four control ears, ABR threshold was not elevated a week after drilling the hole.
内耳前庭出现孔洞会导致噪声暴露后听力损失加剧。需要进一步研究以确定其机制。
评估内耳前庭壁上的孔洞对噪声性听力损失的可能影响。
共对14只沙鼠进行了研究。在这14只动物中，10只分别对每只耳朵进行了基线听神经和脑干诱发电位（ABR）阈值测量（插入式耳机），双耳打开中耳鼓室并在一侧内耳前庭钻一个孔。另一只耳朵进行假手术。在立即重新评估ABR阈值后，这10只动物在4个晚上暴露于113 dB SPL的宽带噪声中，3天后重复进行ABR测量。另外4只一侧前庭有孔洞且未暴露于噪声的动物作为对照。
噪声暴露后，有孔洞一侧耳朵的ABR阈值升高了28.5±9.1 dB，对侧无孔洞耳朵的ABR阈值升高了15.5±7.2 dB（差异显著，p<0.003）。在4只对照耳朵中，钻孔一周后ABR阈值未升高。
