Vanek V, Pícha J, Budesínský M, Sanda M, Jirácek J, Holz R C, Hlavácek J
Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, v.v.i., Flemingovo nám. 2, 166 10 Prague 6, Czech Republic.
Protein Pept Lett. 2010 Mar;17(3):405-9. doi: 10.2174/092986610790780387.
The search for potential inhibitors that target so far unexplored bacterial enzyme mono-N-succinyl-L,L-diaminopimelic acid desuccinylase (DapE) has stimulated a development of methodology for quick and efficient preparation of mono-N-acylated 2,6-diaminopimelic acid (DAP) derivatives bearing the different carboxyl groups or lipophilic moieties on their amino group.
对靶向迄今尚未探索的细菌酶单-N-琥珀酰-L,L-二氨基庚二酸脱琥珀酰酶（DapE）的潜在抑制剂的研究，推动了一种方法的发展，该方法可快速高效地制备在其氨基上带有不同羧基或亲脂性部分的单-N-酰化2,6-二氨基庚二酸（DAP）衍生物。
