Institute of Forensic Medicine, University of Oslo, Oslo, Norway.
Acta Paediatr. 2010 Mar;99(3):384-8. doi: 10.1111/j.1651-2227.2009.01611.x. Epub 2009 Dec 1.
Several studies indicate that the mucosal immune system is stimulated in cases of sudden infant death syndrome (SIDS), and our hypothesis is that this immune reaction is because of an unfavourable combination of functional polymorphisms in the cytokine genes.
Thus, in this study, single nucleotide polymorphisms (SNPs) in the genes encoding IL-6, IL-8, IL-12, IL-13, IL-16, IL-18 and IFNgamma were investigated in 148 SIDS cases, 56 borderline SIDS cases, 41 cases of infectious death and 131 controls.
Regarding genotype distribution, no differences between the investigated groups were found. However, in the SIDS group, the genotypes IL-8 -251AA/AT and IL-8 -781CT/TT were significantly more frequent in the SIDS cases found dead in a prone sleeping position, compared with SIDS cases found dead in other sleeping positions. In addition, there was an association between fever prior to death and the genotype IL-13 +4464GG in the cases of infectious death.
This study indicates that specific interleukin genotypes are a part of a genetic make up that make infants sleeping prone at risk for SIDS.
有几项研究表明，在婴儿猝死综合征（SIDS）病例中，黏膜免疫系统受到刺激，我们的假设是，这种免疫反应是由于细胞因子基因中功能多态性的不利组合所致。
因此，在这项研究中，我们调查了编码白细胞介素-6（IL-6）、白细胞介素-8（IL-8）、白细胞介素-12（IL-12）、白细胞介素-13（IL-13）、白细胞介素-16（IL-16）、白细胞介素-18（IL-18）和干扰素-γ（IFNγ）的基因中的单核苷酸多态性（SNP），共纳入了 148 例 SIDS 病例、56 例边界性 SIDS 病例、41 例感染性死亡病例和 131 例对照。
就基因型分布而言，各研究组之间未发现差异。然而，在 SIDS 组中，与其他睡眠姿势死亡的 SIDS 病例相比，在俯卧位死亡的 SIDS 病例中，IL-8-251AA/AT 和 IL-8-781CT/TT 基因型更为常见。此外，在感染性死亡病例中，发热与 IL-13+4464GG 基因型之间存在关联。
本研究表明，特定的白细胞介素基因型是使婴儿俯卧睡眠易患 SIDS 的遗传构成的一部分。
