Department of Dermatology, Aichi Medical University School of Medicine, Aichi, Japan.
J Dermatol. 2009 Dec;36(12):628-31. doi: 10.1111/j.1346-8138.2009.00732.x.
Palmoplantar hyperhidrosis (PPH) is a disorder characterized by excessive sweating of the palmar surfaces of the hands and feet due to emotional sweating. There have been reports based on family histories, and the involvement of genetic factors has been suggested. Among 410 PPH patients who visited our hospital from August 2006 to October 2008, onset age and family history were investigated in order to prepare pedigree charts, and family histories were confirmed in 147 patients (36%). Between the family history and negative family history (sporadic) groups, no significant differences were seen in onset age, sex or sweat volume. With regard to the patterns of incidence within families, parent-child was the most common at 58%, followed by sibling cases at 18%. The incidence of PPH in three generations was 13%. Pedigree charts prepared based on data obtained by patient interviews suggested autosomal dominant inheritance.
手掌多汗症（PPH）是一种由于情绪性出汗而导致手掌和足底过度出汗的疾病。已有基于家族史的报告，提示遗传因素的参与。在 2006 年 8 月至 2008 年 10 月期间，我院共收治 410 例 PPH 患者，对其发病年龄和家族史进行了调查，以便绘制家系图，并对 147 例患者（36%）的家族史进行了确认。在有家族史和无家族史（散发性）组之间，发病年龄、性别或出汗量均无显著差异。关于家族内发病模式，以亲子关系最为常见（58%），其次为兄弟姐妹病例（18%）。三代 PPH 的发病率为 13%。根据患者访谈获得的数据绘制的家系图提示常染色体显性遗传。
