Department of Dermatology, Kinki University School of Medicine, Osaka, Japan.
J Dermatol. 2009 Dec;36(12):638-42. doi: 10.1111/j.1346-8138.2009.00722.x.
Follicular mucinosis (alopecia mucinosa) is often associated with malignancies including mycosis fungoides and Sézary syndrome, but not adult T-cell leukemia-lymphoma (ATLL). We report a 49-year-old male patient who had pruritic follicular papules and erythemas clinically, and follicular and perifollicular infiltrates and follicular mucin deposition histopathologically. The patient showed 11% of flower-shaped atypical lymphocytes in blood examination and positive human T-cell leukemia virus type 1 antibody in serology, consistent with the chronic type of ATLL. This case seems to be a very rare association of follicular mucinosis and chronic ATLL, suggesting that malignant T cells may have a feature of folliculotropism as well as epidermotropism.
滤泡黏蛋白病（黏蛋白性脱发）常与恶性肿瘤相关，包括蕈样真菌病和 Sezary 综合征，但不包括成人 T 细胞白血病/淋巴瘤（ATLL）。我们报告了 1 例 49 岁男性患者，其临床表现为瘙痒性滤泡性丘疹和红斑，组织病理学表现为滤泡和滤泡周围浸润以及滤泡黏蛋白沉积。该患者血液检查中出现 11%花形异型淋巴细胞，血清学中人类 T 细胞白血病病毒 1 型抗体阳性，符合慢性型 ATLL。该病例似乎是滤泡黏蛋白病和慢性 ATLL 非常罕见的关联，提示恶性 T 细胞可能具有亲滤泡性和亲表皮性特征。
