Department of Biological Sciences, Louisiana State University, Baton Rouge, LA 70803, USA.
BMC Genomics. 2009 Dec 3;10:576. doi: 10.1186/1471-2164-10-576.
YY1 is an epigenetic regulator for a large number of mammalian genes. While performing genome-wide YY1 binding motif searches, we discovered that the olfactory receptor (OLFR) genes have an unusual cluster of YY1 binding sites within their coding regions. The statistical significance of this observation was further analyzed.
About 45% of the olfactory genes in the mouse have a range of 4-8 YY1 binding sites within their respective 1 kb coding regions. Statistical analyses indicate that this enrichment of YY1 motifs has likely been driven by unknown selection pressures at the DNA level, but not serendipitously by some peptides enriched within the OLFR genes. Similar patterns are also detected in the OLFR genes of all mammals analyzed, but not in the OLFR genes of the fish lineage, suggesting a mammal-specific phenomenon.
YY1, or YY1-related transcription factors, may help regulate olfactory receptor genes. Furthermore, the protein-coding regions of vertebrate genes can contain cis-regulatory elements for transcription factor binding as well as codons.
YY1 是大量哺乳动物基因的表观遗传调节剂。在进行全基因组 YY1 结合基序搜索时，我们发现嗅觉受体 (OLFR) 基因在其编码区域内有一个不寻常的 YY1 结合位点簇。进一步分析了这一观察结果的统计学意义。
在小鼠中，大约 45%的嗅觉基因在各自的 1kb 编码区域内有 4-8 个 YY1 结合位点。统计分析表明，这种 YY1 基序的富集很可能是由 DNA 水平上未知的选择压力驱动的，而不是由于 OLFR 基因内某些富集的肽段而偶然发生的。在分析的所有哺乳动物的 OLFR 基因中也检测到了类似的模式，但在鱼类谱系的 OLFR 基因中没有检测到，这表明这是一种哺乳动物特有的现象。
YY1 或 YY1 相关的转录因子可能有助于调节嗅觉受体基因。此外，脊椎动物基因的蛋白质编码区可以包含转录因子结合的顺式调节元件以及密码子。
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