School of Pharmaceutical Sciences, Hebei University, Baoding, China.
J Pharm Pharmacol. 2009 Dec;61(12):1631-5. doi: 10.1211/jpp/61.12.0007.
The aim of this study was to prepare a microsphere formulation in order to mask the bitter taste of azithromycin.
Microspheres of azithromycin with ethyl cellulose were prepared by the modified solvent diffusion method. The microspheres were mixed with other excipients to form orally dry suspensions and the sensory test for taste masking was evaluated.
Results demonstrated that the suspension could significantly mask the bitter taste of azithromycin and the relative bioavailability of suspensions to reference preparations was 102.7%.
The results indicate that the microsphere formulation can be a promising drug carrier for masking the bitter taste of azithromycin.
本研究旨在制备一种微球制剂，以掩盖阿奇霉素的苦味。
采用改良溶剂扩散法制备阿奇霉素乙基纤维素微球。将微球与其他辅料混合制成口服干混悬剂，并对掩味效果进行感官评价。
结果表明，该混悬剂能显著掩盖阿奇霉素的苦味，其相对生物利用度为对照制剂的 102.7%。
结果表明，该微球制剂可作为一种有前途的药物载体，用于掩盖阿奇霉素的苦味。
