Science Strategies, LLC, Charlottesville, VA 22902, USA.
Dermatitis. 2009 Nov-Dec;20(6):338-40.
Pyrethrins are the insecticidally active components of pyrethrum extract, derived from flowers of Chrysanthemum cinerariifolium and used in commercial and consumer insecticide products. Most dermal testing performed with pyrethrum extracts was done before current refined pyrethrum concentrate became available (before 1967).
We analyzed presently commercially available pyrethrum allergen extracts to determine the concentration of pyrethrins and the putative sensitizer pyrethrosin.
Six commercial pyrethrum allergen extracts were purchased from four major allergen suppliers and analyzed for pyrethrin I and pyrethrosin by using a capillary gas chromatograph equipped with a flame ionization detector.
The commercial pyrethrum allergen extracts contained no detectable pyrethrins or pyrethrosin. In comparison, the pyrethrum standard provided by the McLaughlin Gormely King Company, a major refiner of pyrethrum, contained 20% pyrethrins and 0.49% pyrethrosin. No compounds observed in the chromatogram of the refined pyrethrum concentrate were present in the allergen extracts.
Caution should be used when interpreting the results of tests performed with current pyrethrum allergen extracts because pyrethrins and pyrethrosin may not be present. Moreover, unknown components such as high-molecular-weight proteins or other impurities that may cause dermal reactions could be present in significant amounts.
除虫菊素是除虫菊提取物中的杀虫活性成分，来源于除虫菊（ Chrysanthemum cinerariifolium ）的花朵，用于商业和消费者用杀虫剂产品。大多数使用除虫菊提取物进行的皮肤测试是在当前精制除虫菊浓缩物可用之前进行的（1967 年之前）。
我们分析了目前市售的除虫菊过敏原提取物，以确定除虫菊素和潜在的敏化剂除虫菊酯的浓度。
从四个主要过敏原供应商购买了六种商业除虫菊过敏原提取物，并使用配备火焰电离检测器的毛细管气相色谱仪分析了除虫菊素 I 和除虫菊酯。
商业除虫菊过敏原提取物中未检测到除虫菊素或除虫菊酯。相比之下，由除虫菊主要精制商 McLaughlin Gormely King 公司提供的除虫菊标准品含有 20%的除虫菊素和 0.49%的除虫菊酯。在精制除虫菊浓缩物的色谱图中观察到的化合物不存在于过敏原提取物中。
在使用当前除虫菊过敏原提取物进行测试时，应谨慎解释结果，因为可能不存在除虫菊素和除虫菊酯。此外，可能存在高相对分子质量蛋白质或其他可能引起皮肤反应的杂质等未知成分，且含量可能较高。
