Stanford University School of Medicine, Stanford, CA 94305, USA.
Best Pract Res Clin Haematol. 2009 Dec;22(4):483-7. doi: 10.1016/j.beha.2009.08.005.
Leukaemia stem cells (LSCs) are responsible for sustaining and propagating malignant disease, and, as such, are promising targets for therapy. Studies of human LSCs have served an important role in defining the major tenets of the cancer stem cell model, which centre on the frequencies of cancer stem cells, their potential hierarchical organisation and their degree of maturation. LSCs in acute myeloid leukaemia (AML) have recently been studied using mouse syngeneic models of leukaemia induced by MLL oncogenes. These studies have revealed that LSCs are more analogous to progenitor cells and employ embryonic stem cell-like genetic programmes for their maintenance, prompting a refinement of the original cancer stem cell model with important implications for design of therapies to selectively target LSCs.
白血病干细胞（LSCs）负责维持和增殖恶性疾病，因此是治疗的有前途的靶点。对人类 LSCs 的研究在定义癌症干细胞模型的主要原则方面发挥了重要作用，这些原则集中在癌症干细胞的频率、它们的潜在层次组织及其成熟程度上。最近，人们使用由 MLL 癌基因诱导的小鼠同种异体白血病模型研究了急性髓细胞白血病（AML）中的 LSCs。这些研究表明，LSCs 更类似于祖细胞，并采用胚胎干细胞样的遗传程序来维持其自身，这促使对原始癌症干细胞模型进行了改进，对设计选择性靶向 LSCs 的治疗方法具有重要意义。
