Hess Jay L
Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, 413b Stellar Chance Laboratories, Philadelphia, PA 19104, USA.
Trends Mol Med. 2004 Oct;10(10):500-7. doi: 10.1016/j.molmed.2004.08.005.
Rearrangements of the MLL gene, which is located at chromosome 11q23, are associated with aggressive acute leukemias in both children and adults. MLL regulates Hox gene expression through direct promoter binding and histone modification. MLL rearrangements occurring in leukemia include MLL fusion genes, partial tandem duplications of MLL and MLL amplification. MLL fusions and amplification upregulate Hox expression, apparently resulting in a block of hematopoietic differentiation. Future therapies for MLL-associated leukemia might involve blocking Hox gene upregulation by using fusion proteins or inhibiting the activity of Hox proteins themselves.
位于11号染色体q23区域的MLL基因重排与儿童和成人的侵袭性急性白血病相关。MLL通过直接结合启动子和组蛋白修饰来调节Hox基因的表达。白血病中发生的MLL重排包括MLL融合基因、MLL的部分串联重复和MLL扩增。MLL融合和扩增会上调Hox表达，显然导致造血分化受阻。未来针对MLL相关白血病的治疗可能包括使用融合蛋白阻断Hox基因上调或抑制Hox蛋白本身的活性。
