UMR-7191 (LINC), service de radiologie 2, hôpital Hautepierre, université de Strasbourg, CHU de Strasbourg, Strasbourg, France.
J Neuroradiol. 2010 Jul;37(3):189-91. doi: 10.1016/j.neurad.2009.10.001. Epub 2009 Dec 2.
The clinical and radiological presentations of Epstein-Barr virus (EBV) encephalitis are pleomorphic, but a common and characteristic finding is an increased T2-weighted signal in the bilateral thalami and basal ganglia. We report here a case of post-transplant acute limbic encephalitis (PALE) syndrome that was possibly related to EBV infection. Six weeks after hematopoietic stem-cell transplantation, the patient developed confusion and anterograde amnesia. Brain magnetic resonance imaging (MRI) was performed and revealed bi-hippocampal and amygdala signal abnormalities. The technetium-99m single-photon emission computed tomography ((99m)Tc SPECT) imaging confirmed bilateral limbic structural involvement. The clinical, biological and radiological presentations were consistent with a diagnosis of EBV-induced PALE syndrome. To our knowledge, this is the first described case of PALE syndrome possibly related to EBV infection.
爱泼斯坦-巴尔病毒（EBV）脑炎的临床和影像学表现多种多样，但常见且具有特征性的表现是双侧丘脑和基底节区 T2 加权信号增高。我们在此报告一例可能与 EBV 感染相关的移植后急性边缘性脑炎（PALE）综合征病例。造血干细胞移植后 6 周，患者出现意识混乱和顺行性遗忘。行脑磁共振成像（MRI）检查，显示双侧海马和杏仁核信号异常。锝-99m 单光子发射计算机断层扫描（(99m)Tc SPECT）成像证实双侧边缘系统结构受累。临床表现、生物学和影像学表现符合 EBV 诱导的 PALE 综合征的诊断。据我们所知，这是首例可能与 EBV 感染相关的 PALE 综合征病例。
