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药物治疗的精神分裂症患者的伐伦克林和 P50 听觉门控：一项初步研究。

Varenicline and P50 auditory gating in medicated schizophrenic patients: a pilot study.

机构信息

The Denver VAMC VISN19/MIRECC and UC Denver, School of Medicine, Department of Psychiatry, CO 80220, USA.

出版信息

Psychiatry Res. 2010 Jan 30;175(1-2):179-80. doi: 10.1016/j.psychres.2009.01.025. Epub 2009 Dec 2.

DOI:10.1016/j.psychres.2009.01.025
PMID:19959243
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2815213/
Abstract

Most schizophrenic patients have a deficit in auditory sensory gating that appears to be mediated by the alpha-7 nicotinic receptor. This pilot study examines the effects of varenicline, an alpha-7 agonist, on the P50 auditory evoked potential in six schizophrenic patients. The study was canceled because of concerning side effects consistent with those reported by the FDA. However, in this small group of subjects, varenicline did not consistently enhance P50 auditory gating.

摘要

大多数精神分裂症患者存在听觉感觉门控缺陷，这种缺陷似乎是由α-7 烟碱型乙酰胆碱受体介导的。本研究旨在探讨 α-7 烟碱型乙酰胆碱受体激动剂瓦伦尼克林对 6 例精神分裂症患者 P50 听觉诱发电位的影响。但由于与 FDA 报告的副作用一致，该研究被取消。然而，在这一小部分受试者中，瓦伦尼克林并未一致增强 P50 听觉门控。

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