INSERM UMR 866, Equipe Avenir, University of Burgundy, France.
Eur J Surg Oncol. 2010 Mar;36(3):324-8. doi: 10.1016/j.ejso.2009.11.010. Epub 2009 Dec 2.
Hyperthermic intraperitoneal chemotherapy (HIPEC) is a complex, expensive and time-consuming procedure. Despite its good results in the treatment of peritoneal carcinomatosis, these factors have precluded the wider use of this procedure around the world. We hypothesized that HIPEC could be performed by heating the liquid within the abdomen and thus avoiding the need for an external heating circuit and a pump. The aim of this study was to assess the feasibility and safety of an internal heating device for hyperthermic intraperitoneal chemotherapy in an experimental model.
Four large-white pigs underwent one-hour open intraperitoneal hyperthermia with closed abdomen using this new device. Constant stirring of the liquid around the viscera was performed in the first three animals, but not in the fourth one. At the end of the procedure, all of the viscera were carefully examined to look for thermal injury. Any lesion or doubtful area was removed and sent to pathologic examination.
No adverse events occurred during surgery in any of the animals. A temperature of 42 degrees C was reached in an average time of 14 min and maintained homogeneously between 42 degrees C and 43 degrees C for one hour. No visceral injury was detected in the first three animals. Three foci of thermal injury to the mucosa were detected in the absence of stirring (fourth animal).
Heating the solution within the abdomen during hyperthermic intraperitoneal chemotherapy is feasible, safe and achieves perfect thermal homogeneity. This device provides a time-saving inexpensive way to perform intraperitoneal hyperthermic chemotherapy.
腹腔内热化疗（HIPEC）是一种复杂、昂贵且耗时的操作。尽管它在治疗腹膜癌病方面效果良好，但这些因素限制了该操作在全球范围内的广泛应用。我们假设通过加热腹腔内的液体，可以避免使用外部加热回路和泵来进行 HIPEC。本研究旨在评估一种新型腹腔内热疗设备在实验模型中进行腹腔内热化疗的可行性和安全性。
四只大白猪接受了一小时的开腹腹腔内热疗，腹部闭合，使用这种新设备。在前三只动物中，对内脏周围的液体进行了持续搅拌，但第四只动物未进行搅拌。在操作结束时，仔细检查所有内脏，以寻找热损伤。切除任何病变或可疑区域，并送往病理检查。
在所有动物的手术过程中均未发生不良事件。平均 14 分钟即可达到 42°C 的温度，并且在 42°C 和 43°C 之间保持均匀的温度持续一小时。前三只动物的内脏没有损伤。在没有搅拌的情况下（第四只动物），发现了三个粘膜热损伤病灶。
在腹腔内热化疗期间对腹腔内的溶液进行加热是可行、安全的，并且能够达到完美的热均匀性。该设备提供了一种省时、经济的腹腔内热化疗方法。
