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[法国急性病毒性细支气管炎门诊管理共识会议评估:2003年至2008年期间的进展]

[Assessment of the French Consensus Conference for Acute Viral Bronchiolitis on outpatient management: progress between 2003 and 2008].

作者信息

David M, Luc-Vanuxem C, Loundou A, Bosdure E, Auquier P, Dubus J-C

机构信息

Unité de médecine infantile, CHU Timone-Enfants, 264, rue Saint-Pierre, 13385 Marseille cedex 5, France.

出版信息

Arch Pediatr. 2010 Feb;17(2):125-31. doi: 10.1016/j.arcped.2009.10.022. Epub 2009 Dec 2.

Abstract

BACKGROUND

The 2000 French Consensus Conference for Acute Viral Bronchiolitis management underlined clinical practice recommendations.

OBJECTIVE

To assess the impact of these guidelines on management of acute bronchiolitis, 3 and 8 years after publication.

METHODS

A standardized questionnaire was mailed to 762 general practitioners (GPs) in 2003 and 800 GPs in 2008. It described two clinical case scenarios (moderate acute viral bronchiolitis and severe acute bronchiolitis) and inquired about the physician's conduct in each case. The primary outcome was the percentage of responders who described patient management in accordance with current guidelines: correct diagnosis and treating the patient symptomatically in an outpatient setting in the first case and correct diagnosis in addition to requiring an inpatient setting for the second case. Secondary outcome was the percentage of responders who would have given unnecessary or potentially harmful treatments. Physician responses in 2003 and 2008 were compared using the Student t-test and the Chi(2) test. Multivariate analysis was conducted to assess the potential factors associated with good adherence to guidelines.

RESULTS

Nearly 25% of the questionnaires were returned in 2003 and 2008. Patient management was described in accordance with the guidelines in only 6% in 2003 and 20% in 2008 (p< or =0.001). Unnecessary treatments were prescribed in 77% in 2003 vs 60% in 2008 (p<0.001) and potentially dangerous treatments in 38% in 2003 vs 22 % in 2008 (p=0.006). Using multivariate analysis, the GP's age was inversely correlated with adherence to clinical recommendations (adjusted odds ratio [adOR]=0.93; 95% CI=0.87-0.98; p=0.01). Fifty-four percent of GPs reported knowing these guidelines, but only 57% of them declared that the latter has modified their practice.

DISCUSSION

GPs are still prescribing unnecessary or even potentially dangerous treatments for bronchiolitis. On the other hand, severe cases are correctly diagnosed and well managed in an inpatient setting.

CONCLUSION

Three and 8 years after their publication, adherence to guidelines is insufficient.

摘要

背景

2000年法国急性病毒性细支气管炎管理共识会议强调了临床实践建议。

目的

评估这些指南在发布3年和8年后对急性细支气管炎管理的影响。

方法

2003年向762名全科医生(GP)邮寄了标准化问卷,2008年向800名全科医生邮寄了问卷。问卷描述了两种临床病例情况(中度急性病毒性细支气管炎和重度急性细支气管炎),并询问了医生在每种情况下的处理方式。主要结果是按照当前指南描述患者管理的应答者百分比:第一种情况下正确诊断并在门诊对症治疗,第二种情况下除正确诊断外还需要住院治疗。次要结果是给予不必要或潜在有害治疗的应答者百分比。使用学生t检验和卡方检验比较2003年和2008年医生的回答。进行多变量分析以评估与良好遵循指南相关的潜在因素。

结果

2003年和2008年分别有近25%的问卷被返回。2003年只有6%的患者管理符合指南,2008年为20%(p≤0.001)。2003年77%的患者接受了不必要的治疗,2008年为60%(p<0.001);2003年38%的患者接受了潜在危险的治疗,2008年为22%(p=0.006)。通过多变量分析,全科医生的年龄与遵循临床建议呈负相关(调整后的优势比[adOR]=0.93;95%置信区间=0.87-0.98;p=0.01)。54%的全科医生报告了解这些指南,但只有57%的人表示这些指南改变了他们的做法。

讨论

全科医生仍在为细支气管炎开不必要甚至潜在危险的治疗药物。另一方面,重症病例在住院环境中得到了正确诊断和妥善管理。

结论

在发布3年和8年后,对指南的遵循情况仍然不足。

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