Callaham M, Barton C W, Kayser S
Department of Medicine, University of California, San Francisco.
JAMA. 1991 Mar 6;265(9):1117-22.
Adults resuscitated from nontraumatic cardiac arrest who received intravenous epinephrine in doses chosen by the treating physician and who survived at least 6 hours were studied to determine if high-dose epinephrine produced more complications than standard-dose. A total of 68 patients were enrolled and evaluated for postresuscitation complications attributable to epinephrine, using a two-tailed t test, and contingency analysis. The 33 patients receiving high-dose epinephrine and 35 patients receiving standard-dose epinephrine were similar in demographics and variables known to affect outcome. There was no difference in potential complications between groups except serum calcium, which was 1.97 mmol/L (SD, 0.20) in the high-dose epinephrine group and 2.10 (SD, 0.20) in the standard-dose group. Hospital discharge rates (18% in the high-dose vs 30% in the standard-dose group) and neurological status on discharge were not significantly different. High-dose epinephrine did not produce increased direct complications in this cardiac arrest population compared with standard-dose epinephrine.
对因非创伤性心脏骤停而接受复苏的成年人进行了研究，这些患者接受了由治疗医生选择剂量的静脉注射肾上腺素，且存活至少6小时，以确定高剂量肾上腺素是否比标准剂量产生更多并发症。共纳入68例患者，采用双尾t检验和列联分析，评估肾上腺素所致的复苏后并发症。接受高剂量肾上腺素的33例患者和接受标准剂量肾上腺素的35例患者在人口统计学和已知影响预后的变量方面相似。除血清钙外，两组间潜在并发症无差异，高剂量肾上腺素组血清钙为1.97 mmol/L（标准差，0.20），标准剂量组为2.10（标准差，0.20）。出院率（高剂量组为18%，标准剂量组为30%）和出院时的神经状态无显著差异。与标准剂量肾上腺素相比，高剂量肾上腺素在该心脏骤停人群中并未产生更多直接并发症。
