利福平引起的血小板减少症相关的急性硬脑膜下血肿。

Acute subdural hemorrhage associated with rifampicin-induced thrombocytopenia.

机构信息

Department of Neurology, College of Medicine, Cheju National University, Jeju, South Korea.

出版信息

Neurol Sci. 2010 Apr;31(2):199-200. doi: 10.1007/s10072-009-0187-7. Epub 2009 Dec 4.

PMID:19960218

Abstract

Thrombocytopenia is a major adverse effect of several drug treatments. Rifampicin has been recognized as a cause of immune thrombocytopenia. A 68-year-old woman diagnosed with pulmonary tuberculosis was taking the standard four-drug antituberculosis regimen for 4 months. She presented with decreased responsiveness and headache. Brain MRI revealed subdural hemorrhage along the falx cerebri and high convexity. The platelet count was 8,000 microL(-1). Intracranial hemorrhage due to rifampicin-induced thrombocytopenia has not, to our knowledge, been previously reported. We report a patient with acute subdural hemorrhage associated with rifampicin-induced thrombocytopenia.

摘要

血小板减少症是几种药物治疗的主要不良反应。利福平已被认为是免疫性血小板减少症的一个原因。一名 68 岁女性被诊断患有肺结核，正在服用标准的四联抗结核方案治疗 4 个月。她出现反应迟钝和头痛。脑部 MRI 显示沿大脑镰和高凸面的硬脑膜下血肿。血小板计数为 8000μL(-1)。据我们所知，尚未有报道称利福平引起的血小板减少症导致颅内出血。我们报告了一例与利福平诱导的血小板减少症相关的急性硬脑膜下血肿患者。