Grimes Caris, Lalude Olatunde
Princess Alexandra Hospital NHS Trust, Hamstel Road, Harlow, Essex CM20 1QX, UK.
J Gastrointest Cancer. 2010 Mar;41(1):6-8. doi: 10.1007/s12029-009-9103-x.
Endometrial carcinoma is a relatively common condition which may occur with more than 6,400 new cases diagnosed each year in the UK (Cancer Research UK Statistics http://info.cancerresearchuk.org/cancerstats/types/uterus ). It may occur following hysterectomy especially if associated with prolonged hormone replacement therapy.
We report the case of a 63-year-old lady who presented with a tumour in the sigmoid mesentery 13 years after hysterectomy and following 10 years of tamoxifen therapy for a breast carcinoma. This is the first time that endometrial cancer has been reported as a complication of tamoxifen therapy in the absence of a uterus.
We suggest that endometrial carcinoma remains a differential diagnosis of any pelvic or abdominal mass even after hysterectomy, and a history of intake of oestrogen agonists and antagonists needs to be obtained.
子宫内膜癌是一种相对常见的疾病,在英国每年有超过6400例新病例被诊断出来(英国癌症研究统计数据http://info.cancerresearchuk.org/cancerstats/types/uterus )。它可能在子宫切除术后发生,尤其是与长期激素替代疗法相关时。
我们报告一例63岁女性病例,该患者在子宫切除术后13年,且在因乳腺癌接受10年他莫昔芬治疗后,出现乙状结肠系膜肿瘤。这是首次报道在没有子宫的情况下,子宫内膜癌作为他莫昔芬治疗的并发症。
我们建议,即使在子宫切除术后,子宫内膜癌仍是任何盆腔或腹部肿块的鉴别诊断之一,并且需要了解雌激素激动剂和拮抗剂的摄入史。