Department of Physiology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Phytother Res. 2010 Aug;24(8):1120-5. doi: 10.1002/ptr.3078.
The effect of chronic silymarin (SM) treatment on hyperalgesia, sciatic motor nerve conduction velocity (MNCV) and oxidative stress in streptozotocin (STZ)-diabetic neuropathic rat was evaluated. Rats were divided into control, diabetic, SM-treated control and diabetic, and sodium salisylate (SS)-treated control and diabetic. SM was administered daily at a dose of 100 mg/kg for two months. Finally, hyperalgesia and sciatic MNCV and oxidative stress markers were assessed. Diabetic rats showed a significant deficit in MNCV and markedly exhibited chemical and thermal hyperalgesia, indicating development of diabetic neuropathy. Antioxidant enzyme superoxide dismutase (SOD) level significantly reduced and malondialdehyde (MDA) level significantly increased in diabetic rats compared to control rats; SM treatment significantly ameliorated the alteration in MNCV, hyperalgesia, MDA level and antioxidant enzyme SOD in diabetic rats. These results clearly suggest the potential effect of SM in prevention and treatment of diabetic neuropathy.
研究了慢性水飞蓟素（SM）治疗对链脲佐菌素（STZ）诱导的糖尿病神经病变大鼠痛觉过敏、坐骨运动神经传导速度（MNCV）和氧化应激的影响。将大鼠分为对照组、糖尿病组、SM 治疗对照组和糖尿病组、以及水杨酸钠（SS）治疗对照组和糖尿病组。SM 以 100mg/kg 的剂量每日给药，持续两个月。最后，评估了痛觉过敏和坐骨 MNCV 以及氧化应激标志物。与对照组相比，糖尿病大鼠的 MNCV 明显降低，且表现出化学和热痛觉过敏，表明发生了糖尿病神经病变。与对照组相比，糖尿病大鼠的抗氧化酶超氧化物歧化酶（SOD）水平显著降低，丙二醛（MDA）水平显著升高；SM 治疗可显著改善糖尿病大鼠 MNCV、痛觉过敏、MDA 水平和抗氧化酶 SOD 的改变。这些结果清楚地表明 SM 在预防和治疗糖尿病神经病变方面具有潜在的作用。
