Faculty of Health Sciences, Department of Human Biology, University of Cape Town, Observatory, Cape Town, South Africa.
IUBMB Life. 2010 Feb;62(2):92-102. doi: 10.1002/iub.275.
Tbx2 is a member of the T-box family of transcription factors that are crucial in embryonic development. Recent studies suggest that T-box factors may also play a role in controlling cell cycle progression and in the genesis of cancer. Tbx2 has been implicated in several developmental processes such as coordinating cell fate, patterning and morphogenesis of a wide range of tissues and organs including limbs, kidneys, lungs, mammary glands, heart, and craniofacial structures. Importantly, Tbx2 is overexpressed in several cancers including melanoma, small cell lung carcinoma, breast, pancreatic, liver, and bladder cancers and can suppress senescence, a cellular process, which serves as a barrier to cancer development. This review presents a state of the art overview of the role and regulation of Tbx2 in early embryonic development and in cancer.
Tbx2 是 T 盒家族转录因子的成员，在胚胎发育中至关重要。最近的研究表明，T 盒因子可能在控制细胞周期进程和癌症发生中也发挥作用。Tbx2 参与了几个发育过程，如协调细胞命运、广泛组织和器官的模式形成和形态发生，包括四肢、肾脏、肺、乳腺、心脏和颅面结构。重要的是，Tbx2 在几种癌症中过度表达，包括黑色素瘤、小细胞肺癌、乳腺癌、胰腺癌、肝癌和膀胱癌，并且可以抑制衰老，这是一种细胞过程，作为癌症发展的障碍。本综述介绍了 Tbx2 在早期胚胎发育和癌症中的作用和调节的最新进展。
