Department of Transplantation and Pediatric Surgery, Postgraduate School of Medical Science, Kumamoto University, Kumamoto, Japan.
World J Gastroenterol. 2009 Dec 7;15(45):5712-5. doi: 10.3748/wjg.15.5712.
To investigate the effects of a novel Leukotriene B(4) receptor antagonist and/or tacrolimus on ischemia-reperfusion in a rat liver model.
Male Lewis rats were pretreated with ONO-4057 (100 mg/kg) and/or tacrolimus (1 mg/kg) orally, and divided into four experimental groups; group 1 (control), group 2 (ONO-4057), group 3 (tacrolimus), group 4 (ONO-4057 + tacrolimus).
There was a tendency for long survival in the groups treated with tacrolimus alone and ONO-4057 plus tacrolimus. Post-reperfusion serum aspartate aminotransferase levels decreased more significantly in ONO-4057 plus tacrolimus group (P < 0.01), than in the tacrolimus alone group (P < 0.05), compared to controls.
This study demonstrated that pretreatment with ONO-4057 in combination with tacrolimus produced additive effects in a rat model of liver ischemia-reperfusion injury.
研究新型白三烯 B4 受体拮抗剂和/或他克莫司对大鼠肝缺血再灌注损伤的影响。
雄性 Lewis 大鼠经口给予 ONO-4057（100mg/kg）和/或他克莫司（1mg/kg）预处理，分为四组实验；第 1 组（对照组）、第 2 组（ONO-4057 组）、第 3 组（他克莫司组）、第 4 组（ONO-4057+他克莫司组）。
单独给予他克莫司和 ONO-4057 联合他克莫司治疗的大鼠有较长的生存时间趋势。与单独使用他克莫司组相比（P＜0.05），ONO-4057 联合他克莫司组再灌注后血清天冬氨酸转氨酶水平下降更明显（P＜0.01）。
本研究表明，在大鼠肝缺血再灌注损伤模型中，ONO-4057 预处理与他克莫司联合应用可产生相加作用。
