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[放疗及热放疗后乳腺癌消退的形态计量分析]

[Morphometric analysis of regression of breast cancer after radiotherapy and thermoradiotherapy].

作者信息

Monakhov A G, Sumina T V, Davydova L V, Rumiantsev A B, Piatova E D

出版信息

Med Radiol (Mosk). 1991;36(2):20-2.

PMID:1996066
Abstract

A study was made of 50 infiltrating breast carcinomas, stages II-III, treated with a combined method with or without local UHF-hyperthermia. The object of investigation were cytological and histological specimens, histotopographic tumor slices. Methods of mathematical analysis of correlations between tumor tissue regression and parameters of parenchymal differentiation in cytological specimens and an area of tumor nodes were employed. Tumor tissue regression and differentiation of cell elements in cytological specimens showed correlation in the course of combined treatment on the basis of radiotherapy. Insignificant correlation was revealed between a volumetric density of the tumor parenchyma, preserved after combined treatment with UHF-hyperthermia, and parameters of cell differentiation in cytological specimens. Significantly positive correlation was found between an area of tumor nodes and an area of necrotic foci, developing in them after thermoradiotherapy.

摘要

对50例II - III期浸润性乳腺癌患者进行了研究,这些患者采用联合方法治疗,部分接受或未接受局部超高频热疗。研究对象为细胞学和组织学标本、组织拓扑学肿瘤切片。采用数学分析方法研究肿瘤组织消退与细胞学标本中实质分化参数及肿瘤结节面积之间的相关性。在放疗基础上的联合治疗过程中,肿瘤组织消退与细胞学标本中细胞成分的分化显示出相关性。在联合超高频热疗后的肿瘤实质体积密度与细胞学标本中的细胞分化参数之间,发现的相关性不显著。在热放疗后肿瘤结节面积与其中出现的坏死灶面积之间,发现显著正相关。

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