[王不留行抗血管生成作用的研究]
[Study on antiangiogenesis effect of Vaccaria segetalis].
作者信息
Feng Lei, Hua Hui, Qiu Li-Ying, Zhang Lian-Fen, Jin Jian
机构信息
Laboratory of Natural Medicine, Ministry of Education, Jiangnan University, Wuxi 214122, China.
出版信息
Zhong Yao Cai. 2009 Aug;32(8):1256-9.
OBJECTIVE
To study the inhibiting effect of Vaccaria segetalis extracts on neovascularization.
METHODS
The effect of Vaccaria segetalis extracts on the proliferation, migration in vitro and tube formation on Matrigel of endothelial cell (HMEC) in vivo were examined by MTT assay and Matrigel plug assay.
RESULTS
The proliferation and migration of HMEC were inhibited significantly by Vaccaria segetalis extracts in a dose-dependent manner (IC50 = 50 microg/mL). It also inhibited angiogenesis in Matrigel plug mouse model.
CONCLUSION
Vaccaria segetalis extracts can inhibit angiogenensis obviously, and it could be developed as an effective antiangiogenic drug.
目的
研究王不留行提取物对血管新生的抑制作用。
方法
采用MTT法和基质胶栓塞法检测王不留行提取物对内皮细胞（HMEC）体外增殖、迁移及体内基质胶成管的影响。
结果
王不留行提取物能显著抑制HMEC的增殖和迁移，呈剂量依赖性（IC50 = 50微克/毫升）。它还能抑制基质胶栓塞小鼠模型中的血管生成。
结论
王不留行提取物能明显抑制血管生成，有望开发成为一种有效的抗血管生成药物。
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