抗乙型肝炎病毒疫苗免疫的持久性和接受高效抗反转录病毒治疗的垂直感染 HIV 的青少年疫苗复种的反应。
Persistence of vaccine immunity against hepatitis B virus and response to revaccination in vertically HIV-infected adolescents on HAART.
机构信息
Division of Pediatric Infectious Diseases, Federal University of São Paulo, São Paulo, Brazil.
出版信息
Vaccine. 2010 Feb 10;28(6):1606-12. doi: 10.1016/j.vaccine.2009.11.045. Epub 2009 Dec 2.
Humoral immune response to vaccine antigens is known to be reduced in perinatally HIV-infected children. Lymphocyte immunophenotyping, humoral immunity to hepatitis B after primary immunization and response to revaccination were evaluated in 40 HIV-infected adolescents on HAART and 23 healthy age-matched controls. Anti-HBs antibody levels >or=10 mIU/mL were found in 18/40 (40.5%) of the HIV-infected adolescents and 18/23 (78.3%) of the HIV-negative adolescents from Control group. Adolescents of HIV group with anti-HBs>or=1 0 mIU/mL presented a higher CD4+ T cell percentage, higher naïve and central memory CD8+ T cell percentages and lower immune activation markers. After revaccination, 12/18 (66.7%) adolescents of HIV group responded. Those adolescents who did not respond to revaccination presented a lower CD4+ T cell percentage, higher immune activation markers and more frequently detectable HIV viral load. We concluded that lower immune activation, higher CD4+ T cell percentage and better control of HIV replication may be associated with hepatitis B vaccine response.
已知围生期感染 HIV 的儿童对疫苗抗原的体液免疫反应降低。对接受高效抗逆转录病毒治疗（HAART）的 40 名 HIV 感染青少年和 23 名年龄匹配的健康对照组进行淋巴细胞免疫表型、初次免疫后乙型肝炎的体液免疫和再接种反应评估。在 40 名 HIV 感染青少年中，有 18/40（40.5%）的人抗-HBs 抗体水平>或=10 mIU/mL，而在对照组 23 名 HIV 阴性青少年中，有 18/23（78.3%）的人抗-HBs 抗体水平>或=10 mIU/mL。HIV 组中抗-HBs>或=10 mIU/mL 的青少年具有更高的 CD4+T 细胞百分比、更高的幼稚和中央记忆 CD8+T 细胞百分比以及更低的免疫激活标志物。在再接种后，12/18（66.7%）名 HIV 组青少年有反应。那些对再接种没有反应的青少年表现出更低的 CD4+T 细胞百分比、更高的免疫激活标志物和更频繁可检测到的 HIV 病毒载量。我们得出结论，较低的免疫激活、较高的 CD4+T 细胞百分比和更好地控制 HIV 复制可能与乙型肝炎疫苗反应有关。
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