I.R.I.B.H.M., Université Libre de Bruxelles, Campus Erasme, Route de Lennik 808, B - 1070 Bruxelles, Belgium.
Mol Cell Endocrinol. 2010 May 28;321(1):3-19. doi: 10.1016/j.mce.2009.11.015. Epub 2009 Dec 3.
The study of normal signal transduction pathways regulating the proliferation and differentiation of a cell type allows to predict and to understand the perversions of these pathways which lead to tumorigenesis. In the case of the human thyroid cell, three cascades are mostly involved in tumorigenesis: The pathways and genetic events affecting them are described. Caveats in the use of models and the interpretation of results are formulated and the still pending questions are outlined.
研究正常信号转导通路对细胞类型的增殖和分化的调控，可以预测和理解导致肿瘤发生的这些通路的异常。在人类甲状腺细胞的情况下，有三个级联反应主要涉及肿瘤发生：描述了影响它们的途径和遗传事件。对模型的使用和结果的解释提出了注意事项，并概述了仍未解决的问题。
