Sharma Paresh, Gurumurthy Srividya, Duncan Robert, Nakhasi Hira L, Salotra Poonam
Institute of Pathology (ICMR), Safdarjung Hospital Campus, New Delhi, India.
Parasitol Int. 2010 Jun;59(2):262-4. doi: 10.1016/j.parint.2009.11.003. Epub 2009 Dec 4.
In Old World Leishmania infections in India, Leishmania donovani is responsible for visceral leishmaniasis (VL) and post kala-azar dermal leishmaniasis (PKDL) while L. tropica is responsible for cutaneous leishmaniasis (CL) in humans. The molecular differences between the two species of Leishmania and within the same species causing distinct pathologies that govern the outcome of infection and pathogenesis in the human host are unknown. Quantitative expression of selected genes was evaluated directly in lesion tissues of VL, PKDL and CL patients. Assessment of in vivo mRNA level highlighted substantial differences in gene expression patterns, providing an indication of the genes involved in pathogenesis in the three different forms of Leishmaniasis.
在印度的旧大陆利什曼原虫感染中，杜氏利什曼原虫导致内脏利什曼病（VL）和黑热病后皮肤利什曼病（PKDL），而热带利什曼原虫导致人类皮肤利什曼病（CL）。导致不同病理状况、决定人类宿主感染结果和发病机制的两种利什曼原虫之间以及同一物种内的分子差异尚不清楚。直接在VL、PKDL和CL患者的病变组织中评估了选定基因的定量表达。对体内mRNA水平的评估突出了基因表达模式的显著差异，这表明了三种不同形式利什曼病发病机制中涉及的基因。
