日本非小细胞肺癌患者外显子19和21中表皮生长因子受体（EGFR）的双重激活体细胞突变。 - Suppr

Epidermal growth factor receptor (EGFR) double-activating somatic mutations in exons 19 and 21 in Japanese non-small cell lung cancer patients.

作者信息

Masago Katsuhiro, Fujita Shiro, Kim Young Hak, Ichikawa Masataka, Hatachi Yukimasa, Fukuhara Akiko, Nagai Hiroki, Irisa Kaoru, Mio Tadashi, Mishima Michiaki

出版信息

Cancer Genet Cytogenet. 2009 Dec;195(2):179-82. doi: 10.1016/j.cancergencyto.2009.06.025.

DOI:10.1016/j.cancergencyto.2009.06.025

PMID:19963121

Abstract

摘要

相似文献

Epidermal growth factor receptor (EGFR) double-activating somatic mutations in exons 19 and 21 in Japanese non-small cell lung cancer patients.日本非小细胞肺癌患者外显子19和21中表皮生长因子受体（EGFR）的双重激活体细胞突变。

Cancer Genet Cytogenet. 2009 Dec;195(2):179-82. doi: 10.1016/j.cancergencyto.2009.06.025.

Update on epidermal growth factor receptor mutations in non-small cell lung cancer.非小细胞肺癌中表皮生长因子受体突变的最新进展

Clin Cancer Res. 2006 Dec 15;12(24):7232-41. doi: 10.1158/1078-0432.CCR-06-0658.

Sequential occurrence of non-small cell and small cell lung cancer with the same EGFR mutation.非小细胞肺癌和小细胞肺癌先后发生且具有相同的表皮生长因子受体（EGFR）突变

Lung Cancer. 2007 Dec;58(3):411-3. doi: 10.1016/j.lungcan.2007.05.014. Epub 2007 Jun 29.

Epidermal growth factor receptor gene amplification in surgical resected Japanese lung cancer.手术切除的日本肺癌中表皮生长因子受体基因扩增

Lung Cancer. 2009 Jun;64(3):295-300. doi: 10.1016/j.lungcan.2008.10.005. Epub 2008 Dec 5.

Functional analysis of epidermal growth factor receptor (EGFR) mutations and potential implications for EGFR targeted therapy.表皮生长因子受体（EGFR）突变的功能分析及其对EGFR靶向治疗的潜在影响。

Clin Cancer Res. 2009 Jan 15;15(2):460-7. doi: 10.1158/1078-0432.CCR-08-1757.

Single-molecule detection of epidermal growth factor receptor mutations in plasma by microfluidics digital PCR in non-small cell lung cancer patients.通过微流控数字PCR对非小细胞肺癌患者血浆中表皮生长因子受体突变进行单分子检测。

Clin Cancer Res. 2009 Mar 15;15(6):2076-84. doi: 10.1158/1078-0432.CCR-08-2622. Epub 2009 Mar 10.

Detection and comparison of epidermal growth factor receptor mutations in cells and fluid of malignant pleural effusion in non-small cell lung cancer.非小细胞肺癌恶性胸腔积液细胞及积液中表皮生长因子受体突变的检测与比较

Lung Cancer. 2008 May;60(2):175-82. doi: 10.1016/j.lungcan.2007.10.011. Epub 2007 Dec 3.

Somatic mutations of EGFR, ERBB2, ERBB3 and ERBB4 in juxtamembrane activating domains are rare in non-small cell lung cancers.在非小细胞肺癌中，EGFR、ERBB2、ERBB3和ERBB4在近膜激活结构域的体细胞突变很少见。

APMIS. 2010 Jan;118(1):83-4. doi: 10.1111/j.1600-0463.2009.02565.x.

Restoration of tumour suppressor hsa-miR-145 inhibits cancer cell growth in lung adenocarcinoma patients with epidermal growth factor receptor mutation.肿瘤抑制因子hsa-miR-145的恢复可抑制表皮生长因子受体突变的肺腺癌患者的癌细胞生长。

Eur J Cancer. 2009 Aug;45(12):2197-206. doi: 10.1016/j.ejca.2009.04.039. Epub 2009 Jun 1.

Correlation between morphology and EGFR mutations in lung adenocarcinomas Significance of the micropapillary pattern and the hobnail cell type.肺腺癌形态学与表皮生长因子受体（EGFR）突变之间的相关性：微乳头模式和鞋钉样细胞类型的意义

Lung Cancer. 2009 Feb;63(2):235-40. doi: 10.1016/j.lungcan.2008.04.017. Epub 2008 Jun 20.

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Clinical significance of serum EGFR gene mutation and serum tumor markers in predicting tyrosine kinase inhibitor efficacy in lung adenocarcinoma.血清 EGFR 基因突变和血清肿瘤标志物对预测肺腺癌酪氨酸激酶抑制剂疗效的临床意义。

Clin Transl Oncol. 2019 Aug;21(8):1005-1013. doi: 10.1007/s12094-018-02014-6. Epub 2019 Jan 12.

Clinical Characteristics and Survival Outcomes for Non-Small-Cell Lung Cancer Patients with Epidermal Growth Factor Receptor Double Mutations.表皮生长因子受体双突变非小细胞肺癌患者的临床特征和生存结局。

Biomed Res Int. 2018 Jan 16;2018:7181368. doi: 10.1155/2018/7181368. eCollection 2018.

Detection of EGFR and BRAF mutations by competitive allele-specific TaqMan polymerase chain reaction in lung adenocarcinoma.采用竞争性等位基因特异性TaqMan聚合酶链反应检测肺腺癌中的表皮生长因子受体（EGFR）和B-Raf原癌基因（BRAF）突变

Oncol Lett. 2018 Mar;15(3):3295-3304. doi: 10.3892/ol.2017.7652. Epub 2017 Dec 19.

EGFR-tyrosine kinase inhibitor treatment in a patient with advanced non-small cell lung cancer and concurrent exon 19 and 21 EGFR mutations: A case report and review of the literature.表皮生长因子受体酪氨酸激酶抑制剂治疗晚期非小细胞肺癌合并表皮生长因子受体第19和21外显子同时突变1例报告并文献复习

Oncol Lett. 2016 May;11(5):3546-3550. doi: 10.3892/ol.2016.4409. Epub 2016 Apr 5.

Comparison of ARMS and direct sequencing for detection of EGFR mutation and prediction of EGFR-TKI efficacy between surgery and biopsy tumor tissues in NSCLC patients.在非小细胞肺癌（NSCLC）患者中，比较扩增阻滞突变系统（ARMS）和直接测序法检测手术和活检肿瘤组织中表皮生长因子受体（EGFR）突变及预测EGFR酪氨酸激酶抑制剂（EGFR-TKI）疗效的情况。

Med Oncol. 2014 May;31(5):926. doi: 10.1007/s12032-014-0926-3. Epub 2014 Apr 20.

Spatial and temporal genetic heterogeneity of epidermal growth factor receptor gene status in a patient with non-small cell lung cancer: a case report.非小细胞肺癌患者表皮生长因子受体基因状态的时空遗传异质性：一例报告

J Med Case Rep. 2011 Nov 22;5:553. doi: 10.1186/1752-1947-5-553.

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Epidermal growth factor receptor (EGFR) double-activating somatic mutations in exons 19 and 21 in Japanese non-small cell lung cancer patients.

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