犬心室收缩性心肺压力感受器反射控制的初步研究
Pilot canine investigation of the cardiopulmonary baroreflex control of ventricular contractility.
作者信息
Sala-Mercado Javier A, Chen Xiaoxiao, Hammond Robert L, Ichinose Masashi, O'Leary Donal S, Mukkamala Ramakrishna
机构信息
Department of Physiology, Wayne State University School of Medicine, Detroit, MI 48201 USA.
出版信息
Annu Int Conf IEEE Eng Med Biol Soc. 2009;2009:1852-5. doi: 10.1109/IEMBS.2009.5332622.
We performed a pilot investigation of the cardiopulmonary baroreflex control of ventricular contractility in two conscious dogs. We specifically measured spontaneous beat-to-beat hemodynamic variability before and after the administration of propranolol. We then identified the transfer function relating beat-to-beat fluctuations in central venous pressure (CVP) to maximal ventricular elastance (E(max)) to characterize the cardiopulmonary baroreflex control of ventricular contractility, while accounting for the influences of arterial blood pressure fluctuations on E(max) via the arterial baroreflex and heart rate fluctuations on E(max) via the force-frequency relation. Our major finding is that the cardiopulmonary baroreflex responds to an increase (decrease) in CVP by increasing (decreasing) E(max) via the beta-sympathetic nervous system.
我们对两只清醒犬的心室收缩性的心肺压力反射控制进行了初步研究。我们特别测量了给予普萘洛尔前后自发的逐搏血流动力学变异性。然后，我们确定了将中心静脉压（CVP）的逐搏波动与最大心室弹性（E(max)）相关联的传递函数，以表征心室收缩性的心肺压力反射控制，同时考虑动脉血压波动通过动脉压力反射对E(max)的影响以及心率波动通过力-频率关系对E(max)的影响。我们的主要发现是，心肺压力反射通过β-交感神经系统增加（降低）E(max)来响应CVP的升高（降低）。
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