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用于短期可植入电子设备的体外细胞毒性测试及弹性互连技术的应用

In vitro cytotoxicity testing and the application of elastic interconnection technology for short-term implantable electronics.

作者信息

Brosteaux Dominique, Lippens Evi, Cornelissen Ria, Schacht Etienne, Carta Riccardo, Jourand Philippe, Puers Robert, Axisa Fabrice, Vervust Thomas, Bossuyt Frederick, Vanfleteren Jan

机构信息

CMST, IMEC/Ghent University, Gent-Zwijnaarde, Belgium.

出版信息

Annu Int Conf IEEE Eng Med Biol Soc. 2009;2009:4880-3. doi: 10.1109/IEMBS.2009.5332457.

DOI:10.1109/IEMBS.2009.5332457
PMID:19963633
Abstract

An electronic device was fabricated consisting of 2 flexible electronic circuit islands, interconnected by a 7 cm long elastic interconnection, which could be elongated for at least 50%. This interconnection was based on gold conductor tracks following a 2-D spring pattern, embedded in a biocompatible silicone elastomer. The complete device was embedded in the same silicone elastomer. An in vitro cytotoxicity extraction test, executed on small test-samples in accordance with the ISO 10 993-1 guidelines, revealed that the applied silicone encapsulation to these samples functioned as a good seal for at least 8 days.

摘要

制造了一种电子设备,它由2个柔性电子电路岛组成,通过一条7厘米长的弹性互连连接,该互连可以伸长至少50%。这种互连基于遵循二维弹簧图案的金导体轨道,嵌入生物相容性硅橡胶弹性体中。整个设备嵌入同一种硅橡胶弹性体中。根据ISO 10 993-1指南对小测试样品进行的体外细胞毒性提取试验表明,对这些样品施加的硅橡胶封装至少在8天内起到了良好的密封作用。

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