Qiu Le, Chuttani Ram, Zhang Songhua, Feng Jun, Itani Sara, Fang Hui, Pleskow Douglas, Sawhney Mandeep S, Salahuddin Saira, Modell Mark D, Vitkin Edward, Hanlon Eugene B, Itzkan Irving, Perelman Lev T
Department of Obgyn and Reproductive Biology, Beth Israel Deaconess Medical Center, Harvard University, Boston, MA 02215 USA.
Annu Int Conf IEEE Eng Med Biol Soc. 2009;2009:1997-2000. doi: 10.1109/IEMBS.2009.5333427.
This letter reports the development of an endoscopic polarized scanning spectroscopy (EPSS) instrument compatible with existing endoscopes. This instrument uses light scattering spectroscopy (LSS). In proof-of-principle studies using a single-point instrument, LSS has successfully demonstrated the ability to identify pre-cancer in the epithelial tissues of five different organs, including Barrett's esophagus (BE). The EPSS instrument can provide real time in vivo information on the location of otherwise invisible high grade dysplasia (HGD), a predictor of adenocarcinoma, and thus can serve as a guide for biopsy. It should greatly reduce the time and labor involved in performing screening and obtaining diagnoses, cause less patient discomfort and ensure that fewer biopsies are required for the reliable location of pre-cancerous lesions.
本信函报告了一种与现有内窥镜兼容的内镜偏振扫描光谱仪（EPSS）的研发情况。该仪器采用光散射光谱法（LSS）。在使用单点仪器进行的原理验证研究中，光散射光谱法已成功证明能够识别包括巴雷特食管（BE）在内的五个不同器官上皮组织中的癌前病变。内镜偏振扫描光谱仪可提供关于原本不可见的高级别上皮内瘤变（HGD）（腺癌的一个预测指标）位置的实时体内信息，因此可作为活检的指导。它应能大大减少进行筛查和获得诊断所需的时间和人力，减少患者不适，并确保在可靠定位癌前病变时所需的活检次数更少。
