基于等离子体金纳米颗粒的分子特异性光声成像的灵敏度研究
On sensitivity of molecular specific photoacoustic imaging using plasmonic gold nanoparticles.
作者信息
Mallidi Srivalleesha, Joshi Pratixa P, Sokolov Konstantin, Emelianov Stanislav
机构信息
Department of Biomedical Engineering, University of Texas at Austin, Austin, TX 78712, USA.
出版信息
Annu Int Conf IEEE Eng Med Biol Soc. 2009;2009:6338-40. doi: 10.1109/IEMBS.2009.5333161.
Abstract
Functionalized gold nanospheres undergo receptor mediated aggregation on cancer cells that overexpress the epidermal growth factor receptor (EGFR). This phenomenon leads to a red shift in the plasmon resonance frequency of the EGFR-targeted gold nanoparticles. Previously we demonstrated that highly selective detection of cancer cells can be achieved using the combination of multi-wavelength photoacoustic imaging and molecular specific gold nanoparticles. In this study, we use tissue models to evaluate the sensitivity of molecular specific photoacoustic imaging in detecting cancer cells labeled with EGFR-targeted gold nanoparticles. The results of our study indicate that highly sensitive detection of cancer cells is feasible using photoacoustic imaging and plasmonic gold nanoparticles.
摘要
功能化金纳米球在过度表达表皮生长因子受体（EGFR）的癌细胞上发生受体介导的聚集。这种现象导致EGFR靶向金纳米颗粒的等离子体共振频率发生红移。此前我们证明，使用多波长光声成像和分子特异性金纳米颗粒的组合可以实现对癌细胞的高选择性检测。在本研究中，我们使用组织模型来评估分子特异性光声成像在检测用EGFR靶向金纳米颗粒标记的癌细胞中的灵敏度。我们的研究结果表明，使用光声成像和等离子体金纳米颗粒对癌细胞进行高灵敏度检测是可行的。
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