用于深入评估关节假体失败的多学科方法。

Multidisciplinary approach for in-deep assessment of joint prosthesis failure.

作者信息

Tessarolo F, Caola I, Piccoli F, Dorigotti P, Demattè E, Molinari M, Malavolta M, Barbareschi M, Caciagli P, Nollo G

机构信息

Interdepartmental Centre for Biotechnologies and Department of Physics, University of Trento, 35100, Trento, Italy.

出版信息

Annu Int Conf IEEE Eng Med Biol Soc. 2009;2009:4254-7. doi: 10.1109/IEMBS.2009.5333602.

DOI:10.1109/IEMBS.2009.5333602

PMID:19964348

Abstract

In spite of advancement in biomaterials and biomechanics, in development of new osteo-integrative materials and coatings, and in macro- micro- component design, a non negligible fraction of the implanted prosthesis fails before the expected lifetime. A prospective observational clinical study has been conducted to define and apply a set of experimental techniques to in-deep assess the failure of joint prosthesis. Microbiological, histological and micro-structural techniques were implemented to specifically address phenomena occurring at the tissue-implant interface. Results obtained from 27 cases of prosthetic joint failure are discussed in terms of sensitivity and specificity. A procedural flow-chart is finally proposed for the assessment of joint prosthesis failure.

摘要

尽管在生物材料和生物力学方面取得了进展，在新型骨整合材料和涂层的开发以及宏观-微观部件设计方面也有所进步，但仍有不可忽视的一部分植入假体在预期寿命之前就失效了。已经开展了一项前瞻性观察性临床研究，以定义并应用一系列实验技术来深入评估关节假体的失效情况。实施了微生物学、组织学和微观结构技术，以专门研究在组织-植入物界面发生的现象。从27例假体关节失效病例中获得的结果从敏感性和特异性方面进行了讨论。最后提出了一个用于评估关节假体失效的程序流程图。